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Suzetrigine Side Effects

The most commonly reported side effects of suzetrigine include off label use, pruritus, and nausea, based on 666 FDA adverse event reports from 2020 to 2025. 3.0% of reports found the drug to be ineffective.

Suzetrigine side effects

Percentages show how often each reaction appears relative to total reports for suzetrigine.

1
Off Label Use19.4%129
2
Pruritus11.1%74
3
Nausea7.8%52
4
Paraesthesia7.7%51
5
Rash7.1%47
6
Dizziness6.8%45
7
Muscle Spasms5.4%36
8
Fatigue4.4%29
9
Somnolence4.2%28
10
Headache3.6%24
11
Hypoaesthesia3.3%22
12
Burning Sensation3.2%21
13
Insomnia3.2%21
14
Diarrhoea3.0%20
15
Drug Ineffective3.0%20

These are voluntary reports and do not establish that suzetrigine caused these reactions.

Report severity

11.9%Serious79 reports
5.0%Hospitalizations33 reports
0.5%Fatal3 reports

Seriousness is determined by the reporter, not by OpenClaim.

Suzetrigine drug interactions

Other drugs that appear in adverse event reports alongside suzetrigine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Acetaminophen0.6%4
2
Gabapentin0.5%3
3
Tramadol-hydrochloride0.5%3
4
Meloxicam0.3%2
5
Clonazepam0.3%2
6
Dexamethasone0.3%2
7
Diphenhydramine0.3%2
8
Ruxolitinib0.3%2
9
Fentanyl0.3%2
10
Avapritinib0.3%2
11
Sodium-oxybate0.3%2
12
Adalimumab0.2%1
13
Lisinopril0.2%1
14
Amphetamine0.2%1
15
Dextroamphetamine0.2%1

Taken alongside

1
Acetaminophen8.1%54
2
Oxycodone5.4%36
3
Gabapentin4.4%29
4
Tramadol-hydrochloride2.9%19
5
Aspirin2.6%17
6
Ibuprofen2.4%16
7
Celecoxib2.0%13
8
Duloxetine-hydrochloride1.8%12
9
Meloxicam1.8%12
10
Ergocalciferol1.7%11
11
Ondansetron1.5%10
12
Famotidine1.5%10
13
Magnesium-acetate-tetrahydrate1.4%9
14
Buspirone-hydrochloride1.4%9
15
Pregabalin1.2%8

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports suzetrigine side effects

44.0% of suzetrigine adverse event reports involve female patients and 24.8% involve male patients. The largest age group is elderly at 52%. These figures reflect who reports side effects, not underlying risk.

Sex

Female44.0%
Male24.8%
Unknown31.2%

Age group

< 20.0%
2–110.0%
12–170.0%
18–6448.3%
65+51.7%

What is suzetrigine used for

Conditions and purposes for which patients were taking suzetrigine when the adverse event was reported.

ArthralgiaArthritisAutoimmune ThyroiditisAutonomic Nervous System ImbalanceBack DisorderBack PainBone PainCancer PainCervicogenic HeadacheChronic Fatigue SyndromeChronic Idiopathic Pain SyndromeComplex Regional Pain SyndromeDevelopmental Hip DysplasiaDysmenorrhoeaEhlers-danlos Syndrome

Showing 15 of 69 indications

Suzetrigine brand names and reporting trend

Suzetrigine is sold under the brand name Journavx.

Brand names

Journavx156

Quarterly reports (20202025)

20202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking suzetrigine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.