OpenClaim

Suvorexant Side Effects

The most commonly reported side effects of suvorexant include nightmare, somnolence, and insomnia, based on 12,693 FDA adverse event reports from 2014 to 2025. 23.6% of reports found the drug to be ineffective.

Suvorexant side effects

Percentages show how often each reaction appears relative to total reports for suvorexant.

1
Drug Ineffective23.6%2,994
2
Nightmare5.8%736
3
Somnolence5.7%726
4
Insomnia5.3%674
5
Abnormal Dreams4.7%599
6
Headache4.2%535
7
Feeling Abnormal3.8%485
8
Nausea3.0%382
9
Hallucination2.9%372
10
Fatigue2.8%353
11
No Adverse Event2.8%350
12
Dizziness2.6%325
13
Anxiety2.4%308
14
Fall2.0%259
15
Off Label Use2.0%258

These are voluntary reports and do not establish that suvorexant caused these reactions.

Report severity

34.2%Serious4,346 reports
15.6%Hospitalizations1,977 reports
5.4%Fatal688 reports

Seriousness is determined by the reporter, not by OpenClaim.

Suvorexant drug interactions

Other drugs that appear in adverse event reports alongside suvorexant. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Sodium-oxybate2.0%254
2
Quetiapine-fumarate1.2%153
3
Zolpidem-tartrate1.2%148
4
Aripiprazole0.9%116
5
Trazodone-hydrochloride0.8%105
6
Eszopiclone0.7%88
7
Lamotrigine0.7%87
8
Pembrolizumab0.6%78
9
Duloxetine-hydrochloride0.6%77
10
Pregabalin0.6%75
11
Risperidone0.6%74
12
Omeprazole0.5%67
13
Nivolumab0.5%66
14
Lorazepam0.5%62
15
Olanzapine0.5%60

Taken alongside

1
Acetaminophen4.6%584
2
Zolpidem-tartrate4.5%566
3
Amlodipine4.4%554
4
Aspirin4.3%551
5
Ergocalciferol4.3%543
6
Levothyroxine-sodium4.2%529
7
Gabapentin3.8%476
8
Clonazepam3.5%445
9
Trazodone-hydrochloride3.4%437
10
Furosemide3.4%429
11
Alprazolam3.4%427
12
Magnesium-oxide3.4%426
13
Atorvastatin-calcium3.2%405
14
Omeprazole3.0%384
15
Quetiapine-fumarate2.9%374

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports suvorexant side effects

53.9% of suvorexant adverse event reports involve female patients and 35.2% involve male patients. The largest age group is elderly at 50%. These figures reflect who reports side effects, not underlying risk.

Sex

Female53.9%
Male35.2%
Unknown10.9%

Age group

< 20.2%
2–110.2%
12–170.4%
18–6449.0%
65+50.2%

What is suvorexant used for

Conditions and purposes for which patients were taking suvorexant when the adverse event was reported.

Abnormal BehaviourAdjustment DisorderAlcohol Withdrawal SyndromeAnxietyAnxiety DisorderAphasiaAntidepressant TherapyAnxietyAnxiety DisorderAutism Spectrum DisorderBack PainBipolar DisorderBipolar I DisorderBlindnessBrain Injury

Showing 15 of 145 indications

Suvorexant brand names and reporting trend

Suvorexant is sold under the brand name Suvorexant.

Brand names

Suvorexant586

Quarterly reports (20142025)

20142016202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking suvorexant with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.