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Suprofen Side Effects

The most commonly reported side effects of suprofen include cardiac arrest, off label use, and acute kidney injury, based on 47 FDA adverse event reports from 2005 to 2025.

Suprofen side effects

Percentages show how often each reaction appears relative to total reports for suprofen.

1
Cardiac Arrest10.6%5
2
Off Label Use8.5%4
3
Acute Kidney Injury8.5%4
4
Asthenia6.4%3
5
Febrile Neutropenia6.4%3
6
Pyrexia6.4%3
7
Herpes Zoster4.3%2
8
Drug Interaction4.3%2
9
General Physical Health Deterioration4.3%2
10
Decreased Appetite4.3%2
11
Cutaneous Vasculitis4.3%2
12
Death4.3%2
13
Palmar-plantar Erythrodysaesthesia Syndrome4.3%2
14
Cardiac Tamponade4.3%2
15
Hypotension4.3%2

These are voluntary reports and do not establish that suprofen caused these reactions.

Report severity

93.6%Serious44 reports
63.8%Hospitalizations30 reports
21.3%Fatal10 reports

Seriousness is determined by the reporter, not by OpenClaim.

Suprofen drug interactions

Other drugs that appear in adverse event reports alongside suprofen. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Bevacizumab12.8%6
2
Rivaroxaban12.8%6
3
Acetaminophen10.6%5
4
Cyclophosphamide8.5%4
5
Tramadol-hydrochloride8.5%4
6
Metoclopramide-hydrochloride8.5%4
7
Caspofungin-acetate6.4%3
8
Doxorubicin-hydrochloride4.3%2
9
Vincristine-sulfate4.3%2
10
Duloxetine-hydrochloride4.3%2
11
Aspirin4.3%2
12
Omalizumab4.3%2
13
Sorafenib-tosylate4.3%2
14
Regorafenib4.3%2
15
Amiodarone-hydrochloride4.3%2

Taken alongside

1
Esomeprazole14.9%7
2
Furosemide14.9%7
3
Acetaminophen14.9%7
4
Alprazolam12.8%6
5
Methylprednisolone12.8%6
6
Omeprazole12.8%6
7
Levothyroxine-sodium10.6%5
8
Dexchlorpheniramine-maleate8.5%4
9
Prednisolone8.5%4
10
Sodium-chloride8.5%4
11
Amoxicillin8.5%4
12
Pregabalin8.5%4
13
Nifedipine8.5%4
14
Sulfamethoxazole8.5%4
15
Insulin8.5%4

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports suprofen side effects

46.8% of suprofen adverse event reports involve female patients and 40.4% involve male patients. The largest age group is adult at 44%. These figures reflect who reports side effects, not underlying risk.

Sex

Female46.8%
Male40.4%
Unknown12.8%

Age group

< 20.0%
2–112.8%
12–178.3%
18–6444.4%
65+44.4%

What is suprofen used for

Conditions and purposes for which patients were taking suprofen when the adverse event was reported.

ArthralgiaDrug Toxicity ProphylaxisDrug Use For Unknown IndicationEczemaHeadacheHerpes ZosterMigrainePainProduct Used For Unknown IndicationPainProduct Used For Unknown IndicationStomatitisToothacheWrong Patient Received Product

Suprofen brand names and reporting trend

Suprofen is sold under the brand name Profenal.

Brand names

Profenal43

Quarterly reports (20052025)

2005201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking suprofen with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.