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Sumatriptan Side Effects

The most commonly reported side effects of sumatriptan include headache, migraine, and nausea, based on 51,383 FDA adverse event reports from 2004 to 2025. 10.2% of reports found the drug to be ineffective.

Sumatriptan side effects

Percentages show how often each reaction appears relative to total reports for sumatriptan.

1
Drug Ineffective10.2%5,256
2
Headache6.5%3,322
3
Migraine6.0%3,075
4
Nausea5.6%2,892
5
Fatigue4.6%2,375
6
Drug Ineffective4.3%2,213
7
Pain3.8%1,978
8
Application Site Erythema3.7%1,905
9
Dizziness3.6%1,830
10
Off Label Use3.1%1,571
11
Vomiting3.1%1,570
12
Dyspnoea2.7%1,402
13
Anxiety2.5%1,307
14
Diarrhoea2.5%1,294
15
Product Dose Omission Issue2.4%1,247

These are voluntary reports and do not establish that sumatriptan caused these reactions.

Report severity

46.8%Serious24,067 reports
16.8%Hospitalizations8,621 reports
2.3%Fatal1,169 reports

Seriousness is determined by the reporter, not by OpenClaim.

Sumatriptan drug interactions

Other drugs that appear in adverse event reports alongside sumatriptan. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Sodium-oxybate5.4%2,763
2
Adalimumab2.9%1,496
3
Erenumab-aooe2.6%1,318
4
Topiramate2.5%1,277
5
Naproxen2.4%1,233
6
Acetaminophen2.3%1,204
7
Ethinyl-estradiol1.5%794
8
Galcanezumab-gnlm1.5%794
9
Pregabalin1.4%739
10
Omeprazole1.4%695
11
Dupilumab1.3%651
12
Gabapentin1.3%649
13
Venlafaxine1.3%646
14
Drospirenone1.2%640
15
Ibuprofen1.2%610

Taken alongside

1
Acetaminophen16.3%8,395
2
Ergocalciferol11.2%5,742
3
Albuterol10.2%5,251
4
Gabapentin9.6%4,914
5
Levothyroxine-sodium9.5%4,891
6
Topiramate9.2%4,738
7
Omeprazole9.0%4,614
8
Ibuprofen8.1%4,148
9
Fluticasone7.9%4,082
10
Ondansetron7.6%3,882
11
Aspirin7.0%3,594
12
Duloxetine-hydrochloride6.1%3,115
13
Oxycodone5.9%3,055
14
Naproxen5.8%2,996
15
Hydrocodone5.7%2,924

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports sumatriptan side effects

78.0% of sumatriptan adverse event reports involve female patients and 13.7% involve male patients. The largest age group is adult at 85%. These figures reflect who reports side effects, not underlying risk.

Sex

Female78.0%
Male13.7%
Unknown8.4%

Age group

< 20.8%
2–110.3%
12–171.7%
18–6484.7%
65+12.6%

What is sumatriptan used for

Conditions and purposes for which patients were taking sumatriptan when the adverse event was reported.

Abdominal PainAbortion InducedAccident At WorkAccidental ExposureAccidental Exposure To ProductAnalgesiaAnalgesic TherapyAnkylosing SpondylitisAnxietyArnold-chiari MalformationArthralgiaAsthmaAbdominal MigraineAcute Coronary SyndromeAdverse Drug Reaction

Showing 15 of 277 indications

Sumatriptan brand names and reporting trend

Sumatriptan is sold under brand names including Sumatriptan; Naproxen Sodium, Treximet.

Brand names

Sumatriptan; Naproxen Sodium20,508
Treximet9,299

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking sumatriptan with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.