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Sulfisoxazole Side Effects

The most commonly reported side effects of sulfisoxazole include drug hypersensitivity, pyrexia, and rash, based on 106 FDA adverse event reports from 2004 to 2025. 4.7% of reports found the drug to be ineffective.

Sulfisoxazole side effects

Percentages show how often each reaction appears relative to total reports for sulfisoxazole.

1
Drug Hypersensitivity17.0%18
2
Pyrexia4.7%5
3
Rash4.7%5
4
Pathogen Resistance4.7%5
5
Dizziness4.7%5
6
Nausea4.7%5
7
Headache4.7%5
8
Drug Ineffective4.7%5
9
Nausea3.8%4
10
Oedema Peripheral3.8%4
11
Horner^s Syndrome3.8%4
12
Maternal Exposure During Delivery3.8%4
13
Hypersensitivity3.8%4
14
Diarrhoea3.8%4
15
Weight Decreased2.8%3

These are voluntary reports and do not establish that sulfisoxazole caused these reactions.

Report severity

57.5%Serious61 reports
24.5%Hospitalizations26 reports
6.6%Fatal7 reports

Seriousness is determined by the reporter, not by OpenClaim.

Sulfisoxazole drug interactions

Other drugs that appear in adverse event reports alongside sulfisoxazole. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Erythromycin25.5%27
2
Tetracycline13.2%14
3
Amoxicillin9.4%10
4
Clavulanate-potassium8.5%9
5
Ciprofloxacin8.5%9
6
Acetaminophen7.5%8
7
Lenalidomide6.6%7
8
Ibuprofen5.7%6
9
Cephalexin5.7%6
10
Levofloxacin5.7%6
11
Epinephrine5.7%6
12
Streptomycin-sulfate5.7%6
13
Gentamicin-sulfate4.7%5
14
Metronidazole4.7%5
15
Lidocaine4.7%5

Taken alongside

1
Acetaminophen20.8%22
2
Erythromycin15.1%16
3
Ergocalciferol12.3%13
4
Aspirin11.3%12
5
Prednisone9.4%10
6
Calcium9.4%10
7
Potassium-chloride8.5%9
8
Levothyroxine-sodium8.5%9
9
Gabapentin8.5%9
10
Metformin7.5%8
11
Ibuprofen7.5%8
12
Acyclovir7.5%8
13
Clopidogrel-bisulfate6.6%7
14
Hydrocodone6.6%7
15
Insulin6.6%7

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports sulfisoxazole side effects

62.3% of sulfisoxazole adverse event reports involve female patients and 28.3% involve male patients. The largest age group is adult at 52%. These figures reflect who reports side effects, not underlying risk.

Sex

Female62.3%
Male28.3%
Unknown9.4%

Age group

< 26.2%
2–1110.8%
12–171.5%
18–6452.3%
65+29.2%

What is sulfisoxazole used for

Conditions and purposes for which patients were taking sulfisoxazole when the adverse event was reported.

Antibiotic TherapyBladder DisorderBronchitisColitis UlcerativeConjunctivitisCystitisDrug Use For Unknown IndicationEar InfectionInfectionInfection ProphylaxisIntracranial AneurysmNasopharyngitisNocardiosisOtitis Media AcuteProduct Used For Unknown Indication

Showing 15 of 22 indications

Sulfisoxazole brand names and reporting trend

Sulfisoxazole is sold under brand names including Soxazole, Sulfisoxazole Diolamine, Eryzole.

Brand names

Soxazole39
Sulfisoxazole Diolamine1
Eryzole1

Quarterly reports (20042025)

20042010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking sulfisoxazole with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.