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Sulfanilamide Side Effects

The most commonly reported side effects of sulfanilamide include drug hypersensitivity, rash, and hypersensitivity, based on 148 FDA adverse event reports from 2005 to 2025. 14.2% of reports found the drug to be ineffective.

Sulfanilamide side effects

Percentages show how often each reaction appears relative to total reports for sulfanilamide.

1
Drug Hypersensitivity47.3%70
2
Drug Ineffective14.2%21
3
Rash11.5%17
4
Hypersensitivity10.8%16
5
Migraine10.1%15
6
Therapeutic Product Effect Decreased9.5%14
7
Headache7.4%11
8
Dyspnoea6.8%10
9
Urticaria6.1%9
10
Off Label Use6.1%9
11
Abdominal Discomfort5.4%8
12
Pyrexia5.4%8
13
Meningitis5.4%8
14
Liver Function Test Increased5.4%8
15
Arthralgia5.4%8

These are voluntary reports and do not establish that sulfanilamide caused these reactions.

Report severity

52.7%Serious78 reports
10.8%Hospitalizations16 reports
4.7%Fatal7 reports

Seriousness is determined by the reporter, not by OpenClaim.

Sulfanilamide drug interactions

Other drugs that appear in adverse event reports alongside sulfanilamide. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Adalimumab21.6%32
2
Methotrexate16.9%25
3
Penicillin16.2%24
4
Etanercept11.5%17
5
Abatacept10.8%16
6
Celecoxib9.5%14
7
Dihydrocodeine-bitartrate8.8%13
8
Sulfasalazine7.4%11
9
Ciprofloxacin6.8%10
10
Budesonide6.8%10
11
Leflunomide6.1%9
12
Sodium-oxybate6.1%9
13
Codeine5.4%8
14
Trimethoprim5.4%8
15
Azithromycin5.4%8

Taken alongside

1
Acetaminophen12.8%19
2
Levothyroxine-sodium10.1%15
3
Albuterol9.5%14
4
Hydroxychloroquine-sulfate8.1%12
5
Ergocalciferol7.4%11
6
Fluticasone7.4%11
7
Ascorbic-acid6.1%9
8
Montelukast-sodium5.4%8
9
Rabeprazole-sodium5.4%8
10
Amlodipine5.4%8
11
Pantoprazole-sodium5.4%8
12
Ibuprofen5.4%8
13
Clonazepam5.4%8
14
Hydromorphone-hydrochloride4.7%7
15
Diclofenac4.7%7

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports sulfanilamide side effects

60.8% of sulfanilamide adverse event reports involve female patients and 18.9% involve male patients. The largest age group is adult at 65%. These figures reflect who reports side effects, not underlying risk.

Sex

Female60.8%
Male18.9%
Unknown20.3%

Age group

< 20.0%
2–112.4%
12–170.0%
18–6464.6%
65+32.9%

What is sulfanilamide used for

Conditions and purposes for which patients were taking sulfanilamide when the adverse event was reported.

Back PainCystitisCapillary DisorderEndocarditisOrganising PneumoniaPneumocystis Jirovecii PneumoniaPneumonia CytomegaloviralProduct Used For Unknown IndicationProduct Used For Unknown IndicationRheumatoid ArthritisVulvovaginal CandidiasisWound Treatment

Sulfanilamide brand names and reporting trend

Sulfanilamide is sold under the brand name Avc.

Brand names

Avc142

Quarterly reports (20052025)

2005201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking sulfanilamide with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.