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Sulfacetamide Side Effects

The most commonly reported side effects of sulfacetamide include drug hypersensitivity, hypersensitivity, and pain, based on 1,641 FDA adverse event reports from 2004 to 2025. 10.0% of reports found the drug to be ineffective.

Sulfacetamide side effects

Percentages show how often each reaction appears relative to total reports for sulfacetamide.

1
Drug Hypersensitivity19.6%322
2
Drug Ineffective10.0%164
3
Hypersensitivity6.1%100
4
Pain5.2%86
5
Nausea4.9%80
6
Off Label Use4.3%70
7
Arthralgia3.9%64
8
Headache3.7%61
9
Rash3.7%61
10
Neutropenia3.7%61
11
Drug Intolerance3.7%60
12
Fatigue3.6%59
13
Hypothyroidism3.4%55
14
Loss Of Personal Independence In Daily Activities3.4%55
15
Chronic Kidney Disease3.3%54

These are voluntary reports and do not establish that sulfacetamide caused these reactions.

Report severity

43.0%Serious705 reports
16.1%Hospitalizations265 reports
4.0%Fatal66 reports

Seriousness is determined by the reporter, not by OpenClaim.

Sulfacetamide drug interactions

Other drugs that appear in adverse event reports alongside sulfacetamide. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Etanercept5.9%97
2
Sulfamethoxazole5.4%88
3
Adalimumab5.2%86
4
Sodium-oxybate5.2%86
5
Trimethoprim4.6%75
6
Prednisolone4.1%68
7
Amoxicillin4.0%65
8
Tocilizumab4.0%65
9
Rituximab3.9%64
10
Certolizumab-pegol3.8%62
11
Lenalidomide3.6%59
12
Clavulanate-potassium3.4%55
13
Omeprazole3.2%53
14
Ticarcillin-disodium3.2%53
15
Dupilumab3.2%53

Taken alongside

1
Acetaminophen14.4%236
2
Ergocalciferol14.1%231
3
Aspirin12.0%197
4
Prednisone11.2%183
5
Albuterol11.0%180
6
Fluticasone10.8%177
7
Omeprazole10.2%167
8
Levothyroxine-sodium9.8%161
9
Gabapentin9.4%155
10
Furosemide8.8%145
11
Atorvastatin-calcium7.6%125
12
Ibuprofen7.4%122
13
Doxycycline7.1%117
14
Lisinopril7.0%115
15
Amlodipine7.0%115

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports sulfacetamide side effects

69.5% of sulfacetamide adverse event reports involve female patients and 24.2% involve male patients. The largest age group is adult at 62%. These figures reflect who reports side effects, not underlying risk.

Sex

Female69.5%
Male24.2%
Unknown6.3%

Age group

< 20.5%
2–111.3%
12–172.9%
18–6462.4%
65+32.9%

What is sulfacetamide used for

Conditions and purposes for which patients were taking sulfacetamide when the adverse event was reported.

AcneAcne ConglobataAcne CysticAdjuvant TherapyAnalgesic TherapyAntibacterial ProphylaxisAntibiotic ProphylaxisAntibiotic TherapyArthralgiaArthritis ReactiveAcneAntiinflammatory TherapyBlepharitisBlood CholesterolBlood Triglycerides Abnormal

Showing 15 of 115 indications

Sulfacetamide brand names and reporting trend

Sulfacetamide is sold under brand names including Triple Sulfa, Sodium Sulfacetamide.

Brand names

Triple Sulfa706
Sodium Sulfacetamide562

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking sulfacetamide with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.