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Sugammadex Side Effects

The most commonly reported side effects of sugammadex include anaphylactic reaction, bradycardia, and cardiac arrest, based on 3,053 FDA adverse event reports from 2009 to 2025. 4.9% of reports found the drug to be ineffective.

Sugammadex side effects

Percentages show how often each reaction appears relative to total reports for sugammadex.

1
Anaphylactic Reaction12.0%365
2
Bradycardia10.3%315
3
Cardiac Arrest7.0%214
4
Anaphylactic Shock6.8%208
5
Bronchospasm6.4%195
6
Hypotension6.0%182
7
Drug Ineffective4.9%149
8
Recurrence Of Neuromuscular Blockade4.2%129
9
Oxygen Saturation Decreased3.4%103
10
Off Label Use3.0%93
11
Blood Pressure Decreased2.5%76
12
Hypoxia2.4%72
13
Drug Interaction2.4%72
14
Dyspnoea2.2%68
15
Tachycardia2.1%65

These are voluntary reports and do not establish that sugammadex caused these reactions.

Report severity

86.6%Serious2,645 reports
34.2%Hospitalizations1,045 reports
4.2%Fatal127 reports

Seriousness is determined by the reporter, not by OpenClaim.

Sugammadex drug interactions

Other drugs that appear in adverse event reports alongside sugammadex. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Rocuronium-bromide24.3%743
2
Propofol16.2%494
3
Fentanyl10.6%325
4
Remifentanil-hydrochloride6.6%202
5
Lidocaine6.3%193
6
Sevoflurane5.3%163
7
Ondansetron5.3%161
8
Dexamethasone4.3%130
9
Acetaminophen4.1%125
10
Desflurane3.7%114
11
Ropivacaine-hydrochloride3.4%105
12
Midazolam3.2%98
13
Sufentanil-citrate3.0%93
14
Ketamine-hydrochloride2.8%86
15
Apomorphine-hydrochloride2.5%76

Taken alongside

1
Propofol22.9%699
2
Rocuronium-bromide20.0%612
3
Fentanyl19.0%581
4
Remifentanil-hydrochloride11.2%342
5
Acetaminophen9.7%297
6
Sevoflurane9.2%280
7
Ondansetron8.5%259
8
Lidocaine7.4%227
9
Dexamethasone6.9%211
10
Cefazolin-sodium6.0%183
11
Midazolam5.9%180
12
Pseudoephedrine5.7%173
13
Phenylephrine4.6%140
14
Epinephrine4.1%124
15
Sodium-chloride3.6%110

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports sugammadex side effects

46.2% of sugammadex adverse event reports involve female patients and 41.8% involve male patients. The largest age group is adult at 58%. These figures reflect who reports side effects, not underlying risk.

Sex

Female46.2%
Male41.8%
Unknown12.0%

Age group

< 23.5%
2–113.9%
12–173.5%
18–6457.6%
65+31.5%

What is sugammadex used for

Conditions and purposes for which patients were taking sugammadex when the adverse event was reported.

Abdominal Hernia RepairAcute Lymphocytic LeukaemiaAnaesthesiaAnaesthesia ProcedureAnaesthesia ReversalAnaphylactic ReactionAnti-nmda AntibodyAppendicectomyArthroscopic SurgeryAbortion Of Ectopic PregnancyAdverse Drug ReactionAdverse EventAnaesthesiaAnaesthesia ProcedureAnaesthesia Reversal

Showing 15 of 154 indications

Sugammadex brand names and reporting trend

Sugammadex is sold under brand names including Sugammadex, Bridion.

Brand names

Sugammadex800
Bridion480

Quarterly reports (20092025)

200920122016202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking sugammadex with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.