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Streptomycin Side Effects

The most commonly reported side effects of streptomycin include drug resistance, pyrexia, and nausea, based on 1,285 FDA adverse event reports from 2004 to 2025. 6.7% of reports found the drug to be ineffective.

#1 Reported: Drug ResistanceAll side effects ↓Top Co-Medication: IsoniazidDrug interactions ↓63% of Reports Are AdultDemographics ↓

Streptomycin side effects

Percentages show how often each reaction appears relative to total reports for streptomycin.

1
Drug Resistance11.4%147
2
Pyrexia8.2%105
3
Drug Ineffective6.7%86
4
Nausea5.7%73
5
Off Label Use5.1%65
6
Drug Hypersensitivity4.7%60
7
Drug Reaction With Eosinophilia And Systemic Symptoms4.6%59
8
Paradoxical Drug Reaction4.5%58
9
Drug-induced Liver Injury3.9%50
10
Tuberculosis3.7%47
11
Anaemia3.0%39
12
Abdominal Pain3.0%38
13
Diarrhoea2.9%37
14
Headache2.9%37
15
Malaise2.9%37

These are voluntary reports and do not establish that streptomycin caused these reactions.

Report severity

91.9%Serious1,181 reports
34.9%Hospitalizations449 reports
16.7%Fatal215 reports

Seriousness is determined by the reporter, not by OpenClaim.

Streptomycin drug interactions

Other drugs that appear in adverse event reports alongside streptomycin. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Isoniazid43.9%564
2
Ethambutol-hydrochloride37.3%479
3
Pyrazinamide34.1%438
4
Rifampin24.2%311
5
Levofloxacin14.9%191
6
Clarithromycin9.4%121
7
Linezolid9.3%119
8
Ciprofloxacin8.2%105
9
Amoxicillin7.1%91
10
Ethionamide7.1%91
11
Moxifloxacin-hydrochloride7.1%91
12
Lamivudine6.7%86
13
Amikacin-sulfate6.1%78
14
Rifabutin6.0%77
15
Efavirenz5.4%69

Taken alongside

1
Ethambutol-hydrochloride20.3%261
2
Isoniazid14.6%188
3
Pyrazinamide14.0%180
4
Levofloxacin8.2%105
5
Rifampin5.8%74
6
Prednisolone4.3%55
7
Clarithromycin3.8%49
8
Ciprofloxacin3.7%47
9
Moxifloxacin-hydrochloride3.6%46
10
Cycloserine2.9%37
11
Ethionamide2.7%35
12
Amoxicillin2.6%34
13
Vancomycin2.5%32
14
Ofloxacin2.5%32
15
Aspirin2.5%32

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports streptomycin side effects

37.4% of streptomycin adverse event reports involve female patients and 47.7% involve male patients. The largest age group is adult at 63%. These figures reflect who reports side effects, not underlying risk.

Sex

Female37.4%
Male47.7%
Unknown14.9%

Age group

< 23.6%
2–117.8%
12–175.3%
18–6463.2%
65+20.1%

What is streptomycin used for

Conditions and purposes for which patients were taking streptomycin when the adverse event was reported.

Abdominal Pain UpperAccidental ExposureActinomycosisAcute SinusitisAntibiotic ProphylaxisAntibiotic TherapyAtypical Mycobacterial InfectionAtypical Mycobacterial Lower Respiratory Tract InfectionAntibiotic ProphylaxisArachnoiditisAtypical Mycobacterial InfectionBacterial InfectionBone TuberculosisBovine TuberculosisBrucellosis

Showing 15 of 116 indications

Streptomycin brand names and reporting trend

Streptomycin is sold under the brand name Streptomycin Sulfate.

Brand names

Streptomycin Sulfate1,433

Quarterly reports (2004–2025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking streptomycin with another medication?

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