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Stavudine Side Effects

The most commonly reported side effects of stavudine include virologic failure, drug resistance, and foetal exposure during pregnancy, based on 6,887 FDA adverse event reports from 2004 to 2025.

Stavudine side effects

Percentages show how often each reaction appears relative to total reports for stavudine.

1
Virologic Failure6.3%436
2
Drug Resistance6.0%413
3
Foetal Exposure During Pregnancy5.1%350
4
Lipodystrophy Acquired4.5%307
5
Viral Mutation Identified4.1%280
6
Immune Reconstitution Syndrome4.0%277
7
Pain4.0%273
8
Treatment Failure3.8%261
9
Emotional Distress3.7%256
10
Anxiety3.6%245
11
Anhedonia3.3%229
12
Lactic Acidosis3.1%213
13
Pathogen Resistance3.1%212
14
Vomiting3.0%210
15
Mitochondrial Toxicity2.9%201

These are voluntary reports and do not establish that stavudine caused these reactions.

Report severity

95.9%Serious6,603 reports
30.0%Hospitalizations2,067 reports
14.1%Fatal974 reports

Seriousness is determined by the reporter, not by OpenClaim.

Stavudine drug interactions

Other drugs that appear in adverse event reports alongside stavudine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Lamivudine59.4%4,092
2
Nevirapine33.1%2,280
3
Ritonavir29.2%2,012
4
Efavirenz28.4%1,958
5
Zidovudine25.8%1,777
6
Didanosine25.4%1,747
7
Tenofovir23.1%1,594
8
Lopinavir18.6%1,282
9
Abacavir16.0%1,104
10
Nelfinavir-mesylate14.6%1,004
11
Indinavir-sulfate11.8%812
12
Saquinavir11.1%763
13
Emtricitabine10.1%697
14
Atazanavir-sulfate8.0%552
15
Raltegravir-potassium6.0%415

Taken alongside

1
Lamivudine17.4%1,198
2
Ritonavir10.0%687
3
Tenofovir8.1%557
4
Zidovudine6.6%453
5
Sulfamethoxazole6.2%426
6
Didanosine5.7%391
7
Efavirenz5.6%387
8
Abacavir5.6%387
9
Trimethoprim5.5%380
10
Lopinavir5.4%375
11
Emtricitabine4.8%329
12
Nelfinavir-mesylate4.8%328
13
Nevirapine4.2%289
14
Atazanavir-sulfate3.6%249
15
Fluconazole3.4%231

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports stavudine side effects

28.7% of stavudine adverse event reports involve female patients and 50.9% involve male patients. The largest age group is adult at 84%. These figures reflect who reports side effects, not underlying risk.

Sex

Female28.7%
Male50.9%
Unknown20.4%

Age group

< 27.0%
2–113.5%
12–173.0%
18–6483.5%
65+3.0%

What is stavudine used for

Conditions and purposes for which patients were taking stavudine when the adverse event was reported.

Acquired Immunodeficiency SyndromeAcute Hiv InfectionAntifungal TreatmentAntiretroviral TherapyAntiviral ProphylaxisAntiviral TreatmentAsymptomatic Hiv InfectionAutoimmune DisorderAcquired Immunodeficiency SyndromeAntiretroviral TherapyChemotherapyChronic Hepatitis CChronic Hepatitis CDrug Exposure During PregnancyDrug Exposure Via Breast Milk

Showing 15 of 89 indications

Stavudine brand names and reporting trend

Stavudine is sold under the brand name Lamivudine; Stavudine.

Brand names

Lamivudine; Stavudine5,280

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking stavudine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.