OpenClaim

Spinosad Side Effects

The most commonly reported side effects of spinosad include pruritus, alopecia, and condition aggravated, based on 44 FDA adverse event reports from 2011 to 2025. 27.3% of reports found the drug to be ineffective.

Spinosad side effects

Percentages show how often each reaction appears relative to total reports for spinosad.

1
Drug Ineffective27.3%12
2
Pruritus11.4%5
3
Alopecia11.4%5
4
Drug Ineffective9.1%4
5
Condition Aggravated6.8%3
6
Pruritus4.5%2
7
Erythema4.5%2
8
Urticaria4.5%2
9
Rash4.5%2
10
Product Quality Issue4.5%2
11
Death4.5%2
12
Seizure4.5%2
13
Abdominal Pain Upper4.5%2
14
Lice Infestation4.5%2
15
Burning Sensation2.3%1

These are voluntary reports and do not establish that spinosad caused these reactions.

Report severity

27.3%Serious12 reports
4.5%Hospitalizations2 reports
4.5%Fatal2 reports

Seriousness is determined by the reporter, not by OpenClaim.

Spinosad drug interactions

Other drugs that appear in adverse event reports alongside spinosad. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Esomeprazole4.5%2
2
Pantoprazole-sodium4.5%2
3
Dupilumab4.5%2
4
Ivermectin2.3%1
5
Palivizumab2.3%1
6
Dimethyl2.3%1
7
Etanercept2.3%1
8
Tasimelteon2.3%1
9
Aztreonam2.3%1
10
Emtricitabine2.3%1
11
Tenofovir2.3%1
12
Efavirenz2.3%1
13
Cobicistat2.3%1
14
Elvitegravir2.3%1
15
Omeprazole2.3%1

Taken alongside

1
Albuterol15.9%7
2
Fluticasone13.6%6
3
Ibuprofen11.4%5
4
Cyclobenzaprine-hydrochloride9.1%4
5
Polyethylene-glycol-33509.1%4
6
Hydroxyzine9.1%4
7
Azithromycin9.1%4
8
Tramadol-hydrochloride6.8%3
9
Sodium-chloride6.8%3
10
Estradiol6.8%3
11
Methylprednisolone6.8%3
12
Acetaminophen6.8%3
13
Atorvastatin-calcium6.8%3
14
Hydrocodone6.8%3
15
Amoxicillin6.8%3

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports spinosad side effects

54.5% of spinosad adverse event reports involve female patients and 22.7% involve male patients. The largest age group is child at 41%. These figures reflect who reports side effects, not underlying risk.

Sex

Female54.5%
Male22.7%
Unknown22.7%

Age group

< 23.7%
2–1140.7%
12–177.4%
18–6433.3%
65+14.8%

What is spinosad used for

Conditions and purposes for which patients were taking spinosad when the adverse event was reported.

AcarodermatitisLice InfestationLice InfestationProduct Used For Unknown IndicationProduct Used For Unknown IndicationScabies

Spinosad brand names and reporting trend

Spinosad is sold under the brand name Natroba.

Brand names

Natroba11

Quarterly reports (20112025)

2011202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking spinosad with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.