OpenClaim

Sparsentan Side Effects

The most commonly reported side effects of sparsentan include dizziness, fatigue, and hypotension, based on 4,208 FDA adverse event reports from 2020 to 2025. 3.1% of reports found the drug to be ineffective.

Sparsentan side effects

Percentages show how often each reaction appears relative to total reports for sparsentan.

1
Dizziness15.0%632
2
Fatigue13.1%552
3
Hypotension11.5%484
4
Product Use In Unapproved Indication7.0%296
5
Nausea7.0%294
6
Headache5.9%249
7
Peripheral Swelling5.6%236
8
Off Label Use5.2%217
9
Pruritus5.0%210
10
Glomerular Filtration Rate Decreased4.0%170
11
Blood Creatinine Increased4.0%168
12
Blood Pressure Decreased3.7%154
13
Product Administration Error3.6%151
14
Blood Potassium Increased3.2%136
15
Product Dose Omission Issue3.2%135

These are voluntary reports and do not establish that sparsentan caused these reactions.

Report severity

17.2%Serious725 reports
6.6%Hospitalizations277 reports
0.6%Fatal24 reports

Seriousness is determined by the reporter, not by OpenClaim.

Sparsentan drug interactions

Other drugs that appear in adverse event reports alongside sparsentan. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Budesonide4.3%179
2
Dapagliflozin0.6%25
3
Lisinopril0.4%16
4
Prednisone0.4%15
5
Losartan-potassium0.3%13
6
Irbesartan0.3%11
7
Amlodipine0.3%11
8
Semaglutide0.2%9
9
Atorvastatin-calcium0.2%8
10
Nifedipine0.2%8
11
Empagliflozin0.2%8
12
Furosemide0.2%7
13
Metoprolol0.1%6
14
Spironolactone0.1%5
15
Carvedilol0.1%5

Taken alongside

1
Dapagliflozin6.7%284
2
Ergocalciferol5.1%213
3
Atorvastatin-calcium4.9%208
4
Amlodipine4.5%190
5
Allopurinol3.2%133
6
Budesonide3.1%129
7
Empagliflozin2.9%122
8
Fish2.5%106
9
Rosuvastatin2.3%95
10
Furosemide2.1%90
11
Prednisone2.0%83
12
Carvedilol1.9%81
13
Aspirin1.9%79
14
Acetaminophen1.8%77
15
Metoprolol1.8%75

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports sparsentan side effects

42.4% of sparsentan adverse event reports involve female patients and 54.8% involve male patients. The largest age group is adult at 82%. These figures reflect who reports side effects, not underlying risk.

Sex

Female42.4%
Male54.8%
Unknown2.8%

Age group

< 2<0.1%
2–110.2%
12–171.1%
18–6481.5%
65+17.1%

What is sparsentan used for

Conditions and purposes for which patients were taking sparsentan when the adverse event was reported.

Acute Kidney InjuryAlport^s SyndromeAnaemiaAortic Valve IncompetenceArthropathyAscitesBence Jones ProteinuriaBenign Prostatic HyperplasiaBlepharitisBlood Glucose AbnormalBlood Immunoglobulin ABlood Test AbnormalBone DisorderChronic Allograft NephropathyChronic Kidney Disease

Showing 15 of 83 indications

Sparsentan brand names and reporting trend

Sparsentan is sold under the brand name Filspari.

Brand names

Filspari57

Quarterly reports (20202025)

202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking sparsentan with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.