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Sparfloxacin Side Effects

The most commonly reported side effects of sparfloxacin include alanine aminotransferase increased, aspartate aminotransferase increased, and hyperlipidaemia, based on 42 FDA adverse event reports from 2004 to 2025.

#1 Reported: Alanine Aminotransferase IncreasedAll side effects ↓Top Co-Medication: RitonavirDrug interactions ↓71% of Reports Are AdultDemographics ↓

Sparfloxacin side effects

Percentages show how often each reaction appears relative to total reports for sparfloxacin.

1
Alanine Aminotransferase Increased11.9%5
2
Aspartate Aminotransferase Increased11.9%5
3
Hyperlipidaemia11.9%5
4
Drug Resistance11.9%5
5
Acute Myocardial Infarction11.9%5
6
Myelofibrosis11.9%5
7
Asthenia11.9%5
8
Myalgia11.9%5
9
Depression11.9%5
10
Inappropriate Schedule Of Product Administration11.9%5
11
Blood Alkaline Phosphatase Increased9.5%4
12
Gamma-glutamyltransferase Increased9.5%4
13
Nausea9.5%4
14
Hepatic Function Abnormal9.5%4
15
Drug Interaction9.5%4

These are voluntary reports and do not establish that sparfloxacin caused these reactions.

Report severity

92.9%Serious39 reports
61.9%Hospitalizations26 reports
11.9%Fatal5 reports

Seriousness is determined by the reporter, not by OpenClaim.

Sparfloxacin drug interactions

Other drugs that appear in adverse event reports alongside sparfloxacin. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Ritonavir19.0%8
2
Abacavir19.0%8
3
Ethambutol-hydrochloride19.0%8
4
Lopinavir16.7%7
5
Clarithromycin16.7%7
6
Ramipril14.3%6
7
Metformin14.3%6
8
Lamivudine11.9%5
9
Sulfamethoxazole11.9%5
10
Bisoprolol-fumarate11.9%5
11
Zidovudine9.5%4
12
Stavudine9.5%4
13
Efavirenz9.5%4
14
Trimethoprim9.5%4
15
Cycloserine9.5%4

Taken alongside

1
Lamivudine14.3%6
2
Stavudine14.3%6
3
Azithromycin14.3%6
4
Prednisolone14.3%6
5
Hydrocortisone14.3%6
6
Ethambutol-hydrochloride11.9%5
7
Sulfamethoxazole11.9%5
8
Pentamidine-isethionate11.9%5
9
Amikacin-sulfate9.5%4
10
Morphine-sulfate9.5%4
11
Hydroxyzine9.5%4
12
Ciprofloxacin9.5%4
13
Prednisone9.5%4
14
Rosuvastatin9.5%4
15
Ezetimibe9.5%4

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports sparfloxacin side effects

38.1% of sparfloxacin adverse event reports involve female patients and 52.4% involve male patients. The largest age group is adult at 71%. These figures reflect who reports side effects, not underlying risk.

Sex

Female38.1%
Male52.4%
Unknown9.5%

Age group

< 20.0%
2–113.6%
12–170.0%
18–6471.4%
65+25.0%

What is sparfloxacin used for

Conditions and purposes for which patients were taking sparfloxacin when the adverse event was reported.

Acute Myeloid LeukaemiaDrug Use For Unknown IndicationInfection ProphylaxisMycobacterium Avium Complex InfectionMyelodysplastic SyndromePneumoniaPneumonia PneumococcalProduct Used For Unknown IndicationProphylaxisPseudomonas InfectionPulmonary TuberculosisProduct Used For Unknown IndicationPulmonary TuberculosisRash PustularSystemic Antibacterial Therapy

Showing 15 of 17 indications

Sparfloxacin brand names and reporting trend

Sparfloxacin is sold under the brand name Zagam.

Brand names

Zagam42

Quarterly reports (2004–2025)

200420202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking sparfloxacin with another medication?

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