OpenClaim

Sonidegib Side Effects

The most commonly reported side effects of sonidegib include muscle spasms, alopecia, and off label use, based on 1,456 FDA adverse event reports from 2015 to 2025. 4.0% of reports found the drug to be ineffective.

Sonidegib side effects

Percentages show how often each reaction appears relative to total reports for sonidegib.

1
Muscle Spasms13.1%191
2
Alopecia7.9%115
3
Off Label Use7.1%104
4
Fatigue6.7%97
5
Death6.5%95
6
Product Use Issue4.9%71
7
Nausea4.8%70
8
Product Dose Omission Issue4.6%67
9
Therapy Cessation4.5%66
10
Ageusia4.3%63
11
Asthenia4.3%62
12
Blood Creatine Phosphokinase Increased4.2%61
13
Weight Decreased4.2%61
14
Decreased Appetite4.1%59
15
Drug Ineffective4.0%58

These are voluntary reports and do not establish that sonidegib caused these reactions.

Report severity

51.7%Serious753 reports
17.9%Hospitalizations261 reports
9.4%Fatal137 reports

Seriousness is determined by the reporter, not by OpenClaim.

Sonidegib drug interactions

Other drugs that appear in adverse event reports alongside sonidegib. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Azacitidine3.6%53
2
Vismodegib2.1%31
3
Docetaxel1.2%17
4
Cisplatin1.0%14
5
Paclitaxel0.9%13
6
Irinotecan-hydrochloride0.7%10
7
Etoposide0.7%10
8
Carboplatin0.7%10
9
Itraconazole0.7%10
10
Gemcitabine0.7%10
11
Celecoxib0.5%8
12
Cyclophosphamide0.5%7
13
Busulfan0.5%7
14
Temozolomide0.5%7
15
Ramipril0.5%7

Taken alongside

1
Amlodipine3.5%51
2
Aspirin3.2%46
3
Metoprolol3.0%43
4
Levothyroxine-sodium2.5%36
5
Ramipril2.4%35
6
Metformin2.3%34
7
Atorvastatin-calcium2.3%34
8
Furosemide1.9%28
9
Pantoprazole-sodium1.9%27
10
Omeprazole1.6%24
11
Allopurinol1.6%24
12
Bisoprolol-fumarate1.5%22
13
Acetaminophen1.4%20
14
Lisinopril1.3%19
15
Gabapentin1.3%19

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports sonidegib side effects

34.2% of sonidegib adverse event reports involve female patients and 55.9% involve male patients. The largest age group is elderly at 73%. These figures reflect who reports side effects, not underlying risk.

Sex

Female34.2%
Male55.9%
Unknown9.9%

Age group

< 2<0.1%
2–110.4%
12–170.6%
18–6426.4%
65+72.5%

What is sonidegib used for

Conditions and purposes for which patients were taking sonidegib when the adverse event was reported.

Acute Myeloid LeukaemiaAdenocarcinoma PancreasBasal Cell CarcinomaBasal Cell Naevus SyndromeBreast CancerBasal Cell CarcinomaBasal Cell Carcinoma MetastaticBasal Cell Naevus SyndromeBasosquamous CarcinomaBasosquamous Carcinoma Of SkinBenign Prostatic HyperplasiaBone NeoplasmCarcinoma In Situ Of SkinChemotherapyChronic Graft Versus Host Disease

Showing 15 of 79 indications

Sonidegib brand names and reporting trend

Sonidegib is sold under the brand name Odomzo.

Brand names

Odomzo610

Quarterly reports (20152025)

2016202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking sonidegib with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.