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Somatropin Side Effects

The most commonly reported side effects of somatropin include drug dose omission by device, device leakage, and device breakage, based on 83,274 FDA adverse event reports from 2004 to 2025.

Somatropin side effects

Percentages show how often each reaction appears relative to total reports for somatropin.

1
Drug Dose Omission By Device20.2%16,821
2
Device Leakage11.7%9,720
3
Device Breakage10.3%8,566
4
Device Mechanical Issue8.2%6,846
5
Device Information Output Issue6.8%5,700
6
Device Issue6.4%5,368
7
Wrong Technique In Device Usage Process5.9%4,875
8
Injection Site Pain5.1%4,268
9
Poor Quality Device Used3.8%3,204
10
Device Use Error3.6%2,989
11
Incorrect Dose Administered3.5%2,877
12
Headache3.4%2,867
13
Device Use Issue3.2%2,668
14
Incorrect Dose Administered By Device3.2%2,650
15
Device Physical Property Issue3.2%2,637

These are voluntary reports and do not establish that somatropin caused these reactions.

Report severity

30.7%Serious25,575 reports
11.7%Hospitalizations9,736 reports
2.6%Fatal2,198 reports

Seriousness is determined by the reporter, not by OpenClaim.

Somatropin drug interactions

Other drugs that appear in adverse event reports alongside somatropin. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Testosterone0.3%277
2
Levothyroxine-sodium0.3%231
3
Hydrocortisone0.2%203
4
Desmopressin-acetate0.1%122
5
Insulin0.1%112
6
Sodium-oxybate0.1%110
7
Metformin0.1%107
8
Dupilumab0.1%107
9
Prednisone0.1%100
10
Amlodipine0.1%100
11
Infliximab0.1%96
12
Methotrexate0.1%84
13
Estradiol<0.1%81
14
Lorazepam<0.1%80
15
Ranitidine<0.1%70

Taken alongside

1
Levothyroxine-sodium5.9%4,946
2
Hydrocortisone3.7%3,082
3
Testosterone1.8%1,477
4
Ergocalciferol1.5%1,247
5
Desmopressin-acetate1.5%1,228
6
Albuterol1.0%831
7
Acetaminophen0.8%665
8
Prednisone0.8%636
9
Metformin0.8%634
10
Fluticasone0.7%610
11
Aspirin0.7%605
12
Omeprazole0.7%574
13
Cetirizine-hydrochloride0.6%535
14
Methylphenidate0.6%534
15
Amlodipine0.6%507

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports somatropin side effects

37.3% of somatropin adverse event reports involve female patients and 55.3% involve male patients. The largest age group is adolescent at 39%. These figures reflect who reports side effects, not underlying risk.

Sex

Female37.3%
Male55.3%
Unknown7.4%

Age group

< 21.6%
2–1136.8%
12–1739.0%
18–6416.9%
65+5.6%

What is somatropin used for

Conditions and purposes for which patients were taking somatropin when the adverse event was reported.

18q Minus Syndrome1p36 Deletion Syndrome22q11.2 Deletion Syndrome3m SyndromeAbnormal Loss Of WeightAbnormal Weight GainAcanthosis NigricansAccidental Exposure To ProductAchondroplasiaAcquired Immunodeficiency SyndromeAcromegalyAcute LeukaemiaAcute Lymphocytic LeukaemiaAcute Myeloid LeukaemiaAcute Pulmonary Oedema

Showing 15 of 1,153 indications

Somatropin brand names and reporting trend

Somatropin is sold under brand names including Accretropin, Zorbtive, Nutropin.

Brand names

Accretropin8,281
Zorbtive3
Nutropin1

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking somatropin with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.