OpenClaim

Sodium Zirconium Cyclosilicate Side Effects

The most commonly reported side effects of sodium zirconium cyclosilicate include death, blood potassium increased, and diarrhoea, based on 3,385 FDA adverse event reports from 2004 to 2025. 2.4% of reports found the drug to be ineffective.

Sodium Zirconium Cyclosilicate side effects

Percentages show how often each reaction appears relative to total reports for sodium zirconium cyclosilicate.

1
Death28.2%953
2
Blood Potassium Increased4.7%160
3
Diarrhoea4.3%146
4
Hyperkalaemia3.8%129
5
Off Label Use3.3%111
6
Constipation3.1%106
7
Nausea2.8%94
8
Cardiac Failure2.4%82
9
Drug Ineffective2.4%81
10
Vomiting2.2%76
11
Acute Kidney Injury2.2%75
12
Renal Failure2.1%72
13
Hypokalaemia2.1%70
14
Pneumonia2.1%70
15
Dyspnoea2.0%68

These are voluntary reports and do not establish that sodium zirconium cyclosilicate caused these reactions.

Report severity

80.4%Serious2,722 reports
26.9%Hospitalizations909 reports
35.1%Fatal1,187 reports

Seriousness is determined by the reporter, not by OpenClaim.

Sodium Zirconium Cyclosilicate drug interactions

Other drugs that appear in adverse event reports alongside sodium zirconium cyclosilicate. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Dapagliflozin3.1%106
2
Tacrolimus1.5%50
3
Budesonide1.3%43
4
Tenapanor-hydrochloride1.2%41
5
Lenalidomide0.9%31
6
Ruxolitinib0.9%31
7
Atorvastatin-calcium0.8%27
8
Valsartan0.7%24
9
Sacubitril0.6%20
10
Furosemide0.6%20
11
Mycophenolate0.6%19
12
Omeprazole0.6%19
13
Aspirin0.5%18
14
Pomalidomide0.5%18
15
Apixaban0.5%16

Taken alongside

1
Aspirin9.6%325
2
Furosemide9.2%313
3
Amlodipine8.5%289
4
Atorvastatin-calcium7.7%260
5
Ergocalciferol7.1%242
6
Insulin7.1%239
7
Acetaminophen6.6%223
8
Sodium-bicarbonate6.3%212
9
Carvedilol5.6%190
10
Metoprolol5.3%180
11
Levothyroxine-sodium4.9%167
12
Gabapentin4.6%156
13
Prednisone4.5%153
14
Pantoprazole-sodium4.2%141
15
Albuterol4.0%135

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports sodium zirconium cyclosilicate side effects

32.2% of sodium zirconium cyclosilicate adverse event reports involve female patients and 51.6% involve male patients. The largest age group is elderly at 68%. These figures reflect who reports side effects, not underlying risk.

Sex

Female32.2%
Male51.6%
Unknown16.2%

Age group

< 2<0.1%
2–110.2%
12–170.1%
18–6431.8%
65+67.9%

What is sodium zirconium cyclosilicate used for

Conditions and purposes for which patients were taking sodium zirconium cyclosilicate when the adverse event was reported.

AlopeciaAcute Kidney InjuryAdenocarcinomaAdverse Drug ReactionAdverse EventAngiopathyAnti-neutrophil Cytoplasmic Antibody Positive VasculitisBlood PhosphorusBlood PotassiumBlood Potassium AbnormalBlood Potassium DecreasedBlood Potassium IncreasedBlood Potassium NormalBlood Pressure AbnormalBrash Syndrome

Showing 15 of 95 indications

Sodium Zirconium Cyclosilicate brand names and reporting trend

Sodium Zirconium Cyclosilicate is sold under the brand name Sodium Zirconium Cyclosilicate.

Brand names

Sodium Zirconium Cyclosilicate880

Quarterly reports (20042025)

200520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking sodium zirconium cyclosilicate with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.