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Sodium Thiosulfate Side Effects

The most commonly reported side effects of sodium thiosulfate include off label use, calciphylaxis, and nausea, based on 526 FDA adverse event reports from 2004 to 2025. 10.1% of reports found the drug to be ineffective.

Sodium Thiosulfate side effects

Percentages show how often each reaction appears relative to total reports for sodium thiosulfate.

1
Off Label Use23.6%124
2
Calciphylaxis16.3%86
3
Nausea11.6%61
4
Drug Ineffective10.1%53
5
Vomiting8.0%42
6
Sepsis4.6%24
7
Metabolic Acidosis4.4%23
8
Condition Aggravated3.6%19
9
Death3.2%17
10
Pruritus3.2%17
11
Calcinosis2.9%15
12
Multiple Organ Dysfunction Syndrome2.7%14
13
Diarrhoea2.3%12
14
Pyrexia2.3%12
15
Hypocalcaemia2.3%12

These are voluntary reports and do not establish that sodium thiosulfate caused these reactions.

Report severity

83.7%Serious440 reports
35.4%Hospitalizations186 reports
15.6%Fatal82 reports

Seriousness is determined by the reporter, not by OpenClaim.

Sodium Thiosulfate drug interactions

Other drugs that appear in adverse event reports alongside sodium thiosulfate. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Cinacalcet-hydrochloride17.9%94
2
Cisplatin14.6%77
3
Warfarin5.3%28
4
Mycophenolate4.8%25
5
Docetaxel4.6%24
6
Sevelamer4.6%24
7
Methotrexate4.0%21
8
Rituximab3.8%20
9
Fentanyl2.9%15
10
Carboplatin2.7%14
11
Infliximab2.7%14
12
Prednisolone2.5%13
13
Calcitriol2.3%12
14
Hydroxychloroquine-sulfate2.3%12
15
Oxycodone2.1%11

Taken alongside

1
Sevelamer8.0%42
2
Aspirin6.1%32
3
Ondansetron5.7%30
4
Cisplatin5.7%30
5
Cinacalcet-hydrochloride5.5%29
6
Warfarin5.5%29
7
Dexamethasone5.3%28
8
Prednisone5.1%27
9
Sodium-chloride4.6%24
10
Methotrexate4.6%24
11
Heparin4.0%21
12
Apixaban4.0%21
13
Diphenhydramine3.4%18
14
Levothyroxine-sodium3.2%17
15
Pantoprazole-sodium3.2%17

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports sodium thiosulfate side effects

51.7% of sodium thiosulfate adverse event reports involve female patients and 35.0% involve male patients. The largest age group is adult at 61%. These figures reflect who reports side effects, not underlying risk.

Sex

Female51.7%
Male35.0%
Unknown13.3%

Age group

< 20.2%
2–114.7%
12–172.7%
18–6461.2%
65+31.1%

What is sodium thiosulfate used for

Conditions and purposes for which patients were taking sodium thiosulfate when the adverse event was reported.

AcneArterial DisorderAzotaemiaAcute Generalised Exanthematous PustulosisAntiallergic TherapyArthropathyAsthmaBlood Parathyroid Hormone IncreasedBlood Parathyroid Hormone IncreasedBone Marrow Conditioning RegimenCalcinosisCalciphylaxisCarbon Monoxide PoisoningChemotherapy Cytokine ProphylaxisChemotherapy Toxicity Attenuation

Showing 15 of 88 indications

Sodium Thiosulfate brand names and reporting trend

Sodium Thiosulfate is sold under the brand name Sodium Thiosulfate.

Brand names

Sodium Thiosulfate556

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking sodium thiosulfate with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.