OpenClaim

Sodium Succinate Side Effects

The most commonly reported side effects of sodium succinate include nausea, pyrexia, and pneumonia, based on 1,078 FDA adverse event reports from 2004 to 2025.

#1 Reported: NauseaAll side effects ↓Top Co-Medication: RituximabDrug interactions ↓47% of Reports Are AdultDemographics ↓

Sodium Succinate side effects

Percentages show how often each reaction appears relative to total reports for sodium succinate.

1
Nausea8.6%93
2
Pyrexia8.3%90
3
Pneumonia8.3%89
4
Diarrhoea8.0%86
5
Off Label Use7.0%75
6
Toxic Epidermal Necrolysis4.9%53
7
Anaemia4.8%52
8
Pruritus4.5%49
9
Vomiting4.2%45
10
Blister4.1%44
11
Multiple Organ Dysfunction Syndrome4.1%44
12
Neutropenia4.0%43
13
Rash4.0%43
14
Condition Aggravated3.9%42
15
Febrile Neutropenia3.5%38

These are voluntary reports and do not establish that sodium succinate caused these reactions.

Report severity

96.6%Serious1,041 reports
58.1%Hospitalizations626 reports
29.1%Fatal314 reports

Seriousness is determined by the reporter, not by OpenClaim.

Sodium Succinate drug interactions

Other drugs that appear in adverse event reports alongside sodium succinate. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Rituximab13.0%140
2
Vincristine-sulfate11.0%119
3
Cyclophosphamide10.8%116
4
Doxorubicin-hydrochloride9.6%104
5
Prednisone9.2%99
6
Prednisolone9.0%97
7
Methotrexate6.9%74
8
Cytarabine6.8%73
9
Dexamethasone5.6%60
10
Metoclopramide-hydrochloride5.5%59
11
Furosemide5.4%58
12
Aspirin5.2%56
13
Tacrolimus5.2%56
14
Acetaminophen4.5%48
15
Mycophenolate4.5%48

Taken alongside

1
Acetaminophen23.1%249
2
Furosemide13.6%147
3
Prednisolone13.5%146
4
Pantoprazole-sodium12.5%135
5
Methylprednisolone10.6%114
6
Dexamethasone10.1%109
7
Omeprazole9.8%106
8
Potassium-chloride9.8%106
9
Insulin9.6%104
10
Sodium-chloride8.3%89
11
Prednisone8.2%88
12
Metoclopramide-hydrochloride8.1%87
13
Hydrocortisone7.9%85
14
Lansoprazole7.8%84
15
Granisetron7.6%82

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports sodium succinate side effects

46.1% of sodium succinate adverse event reports involve female patients and 41.4% involve male patients. The largest age group is adult at 47%. These figures reflect who reports side effects, not underlying risk.

Sex

Female46.1%
Male41.4%
Unknown12.5%

Age group

< 21.8%
2–115.0%
12–172.6%
18–6446.7%
65+43.9%

What is sodium succinate used for

Conditions and purposes for which patients were taking sodium succinate when the adverse event was reported.

Acoustic NeuromaAcute Graft Versus Host DiseaseAcute Lymphocytic LeukaemiaAcute Lymphocytic Leukaemia RecurrentAcute Myeloid LeukaemiaAcute Promyelocytic LeukaemiaAcute Respiratory FailureAdult T-cell Lymphoma/leukaemiaAdverse EventAllergic Transfusion ReactionAnaphylactic ReactionAngiocentric LymphomaAnkylosing SpondylitisAnti-neutrophil Cytoplasmic Antibody Positive VasculitisAplastic Anaemia

Showing 15 of 236 indications

Sodium Succinate brand names and reporting trend

Sodium Succinate is sold under the brand name Sodium Succinate.

Brand names

Sodium Succinate1,962

Quarterly reports (2004–2025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking sodium succinate with another medication?

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