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Sodium Polystyrene Sulfonate Side Effects

The most commonly reported side effects of sodium polystyrene sulfonate include acute kidney injury, hyperkalaemia, and renal failure, based on 5,429 FDA adverse event reports from 2004 to 2025.

Sodium Polystyrene Sulfonate side effects

Percentages show how often each reaction appears relative to total reports for sodium polystyrene sulfonate.

1
Acute Kidney Injury6.9%377
2
Hyperkalaemia5.2%280
3
Renal Failure4.3%234
4
Diarrhoea4.2%227
5
Constipation3.8%207
6
Chronic Kidney Disease3.7%200
7
Anaemia3.3%178
8
Off Label Use2.8%153
9
Death2.8%152
10
Nausea2.7%145
11
Vomiting2.5%135
12
Dyspnoea2.4%133
13
Fall2.4%128
14
Asthenia2.3%125
15
Pyrexia2.3%123

These are voluntary reports and do not establish that sodium polystyrene sulfonate caused these reactions.

Report severity

87.9%Serious4,771 reports
58.3%Hospitalizations3,167 reports
14.5%Fatal786 reports

Seriousness is determined by the reporter, not by OpenClaim.

Sodium Polystyrene Sulfonate drug interactions

Other drugs that appear in adverse event reports alongside sodium polystyrene sulfonate. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Patiromer-sorbitex-calcium11.1%602
2
Furosemide5.2%283
3
Esomeprazole3.3%181
4
Omeprazole3.3%181
5
Mycophenolate3.3%178
6
Tacrolimus3.2%176
7
Pantoprazole-sodium3.1%171
8
Darbepoetin-alfa2.6%140
9
Amlodipine2.6%140
10
Prednisone2.4%132
11
Lenalidomide2.3%125
12
Aspirin2.2%119
13
Ramipril2.0%111
14
Dexamethasone2.0%109
15
Lansoprazole2.0%106

Taken alongside

1
Furosemide25.3%1,373
2
Acetaminophen19.5%1,057
3
Amlodipine19.4%1,052
4
Aspirin18.9%1,026
5
Insulin18.3%994
6
Atorvastatin-calcium12.0%649
7
Sodium-bicarbonate11.7%634
8
Pantoprazole-sodium11.6%632
9
Omeprazole11.5%624
10
Levothyroxine-sodium11.5%623
11
Prednisone11.5%622
12
Metoprolol11.0%598
13
Ergocalciferol10.4%563
14
Allopurinol9.4%509
15
Sevelamer9.1%492

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports sodium polystyrene sulfonate side effects

37.7% of sodium polystyrene sulfonate adverse event reports involve female patients and 55.9% involve male patients. The largest age group is elderly at 57%. These figures reflect who reports side effects, not underlying risk.

Sex

Female37.7%
Male55.9%
Unknown6.4%

Age group

< 21.4%
2–111.1%
12–170.8%
18–6439.2%
65+57.5%

What is sodium polystyrene sulfonate used for

Conditions and purposes for which patients were taking sodium polystyrene sulfonate when the adverse event was reported.

Acute Kidney InjuryAdrenal InsufficiencyAnaplastic Large Cell Lymphoma T- And Null-cell TypesAnxietyArteriovenous Fistula ThrombosisAscitesAcute Kidney InjuryAdverse EventAtypical Haemolytic Uraemic SyndromeBladder CancerBlood CholesterolBlood PotassiumBlood Potassium AbnormalBlood Potassium DecreasedBlood Potassium Increased

Showing 15 of 128 indications

Sodium Polystyrene Sulfonate brand names and reporting trend

Sodium Polystyrene Sulfonate is sold under the brand name Kionex.

Brand names

Kionex1,447

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking sodium polystyrene sulfonate with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.