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Sodium Phosphate Side Effects

The most commonly reported side effects of sodium phosphate include off label use, vomiting, and nausea, based on 3,372 FDA adverse event reports from 2004 to 2025.

Sodium Phosphate side effects

Percentages show how often each reaction appears relative to total reports for sodium phosphate.

1
Off Label Use10.7%360
2
Vomiting10.6%357
3
Nausea10.2%345
4
Sepsis9.2%309
5
Constipation8.9%300
6
Abdominal Pain8.4%284
7
General Physical Health Deterioration7.7%260
8
Abdominal Distension7.7%260
9
Hyponatraemia7.7%260
10
Condition Aggravated7.5%252
11
Multiple Organ Dysfunction Syndrome7.3%245
12
Anaemia7.0%236
13
Ascites7.0%236
14
Cardiogenic Shock6.8%230
15
Stress6.8%228

These are voluntary reports and do not establish that sodium phosphate caused these reactions.

Report severity

92.9%Serious3,132 reports
55.6%Hospitalizations1,876 reports
24.2%Fatal817 reports

Seriousness is determined by the reporter, not by OpenClaim.

Sodium Phosphate drug interactions

Other drugs that appear in adverse event reports alongside sodium phosphate. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Dextrose17.4%587
2
Potassium-chloride17.0%573
3
Sodium-chloride14.9%504
4
Sodium-bicarbonate13.7%462
5
Calcium-chloride11.0%370
6
Magnesium-chloride10.4%350
7
Glutathione-disulfide10.1%342
8
Acetaminophen10.1%340
9
Heparin8.7%293
10
Hydromorphone-hydrochloride8.7%293
11
Allopurinol8.7%292
12
Ceftriaxone-sodium8.6%291
13
Gabapentin8.4%283
14
Metronidazole8.4%283
15
Ondansetron8.3%281

Taken alongside

1
Acetaminophen32.9%1,109
2
Potassium-chloride25.7%865
3
Ondansetron21.3%719
4
Furosemide19.2%646
5
Pantoprazole-sodium16.8%568
6
Sodium-chloride16.1%544
7
Dexamethasone14.8%500
8
Magnesium-sulfate14.7%497
9
Acyclovir13.6%458
10
Insulin13.0%437
11
Lorazepam12.4%417
12
Amlodipine12.4%417
13
Albuterol12.2%413
14
Omeprazole12.1%408
15
Hydromorphone-hydrochloride11.4%384

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports sodium phosphate side effects

40.1% of sodium phosphate adverse event reports involve female patients and 49.1% involve male patients. The largest age group is elderly at 51%. These figures reflect who reports side effects, not underlying risk.

Sex

Female40.1%
Male49.1%
Unknown10.8%

Age group

< 22.5%
2–114.1%
12–173.3%
18–6438.7%
65+51.4%

What is sodium phosphate used for

Conditions and purposes for which patients were taking sodium phosphate when the adverse event was reported.

Abdominal DiscomfortAcute Lymphocytic LeukaemiaAdhesiolysisAdverse EventAllergy ProphylaxisAnti-infective TherapyAntiinflammatory TherapyAphthous StomatitisArthralgiaArthropathyAssisted FertilisationAsthmaAcute Kidney InjuryAdverse EventAdverse Reaction

Showing 15 of 192 indications

Sodium Phosphate brand names and reporting trend

Sodium Phosphate is sold under the brand name Methotrexate Sodium.

Brand names

Methotrexate Sodium4,309

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking sodium phosphate with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.