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Sodium Nitroprusside Side Effects

The most commonly reported side effects of sodium nitroprusside include pain, renal failure, and injury, based on 592 FDA adverse event reports from 2004 to 2025. 8.8% of reports found the drug to be ineffective.

Sodium Nitroprusside side effects

Percentages show how often each reaction appears relative to total reports for sodium nitroprusside.

1
Pain30.4%180
2
Renal Failure30.1%178
3
Injury28.9%171
4
Anxiety26.7%158
5
Unevaluable Event26.4%156
6
Fear24.7%146
7
Renal Injury21.5%127
8
Emotional Distress21.1%125
9
Anhedonia18.6%110
10
Stress18.1%107
11
Renal Impairment17.4%103
12
Multi-organ Failure13.3%79
13
Death11.5%68
14
Depression9.5%56
15
Drug Ineffective8.8%52

These are voluntary reports and do not establish that sodium nitroprusside caused these reactions.

Report severity

92.1%Serious545 reports
44.3%Hospitalizations262 reports
28.9%Fatal171 reports

Seriousness is determined by the reporter, not by OpenClaim.

Sodium Nitroprusside drug interactions

Other drugs that appear in adverse event reports alongside sodium nitroprusside. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Aprotinin30.7%182
2
Nitroglycerin3.5%21
3
Heparin3.4%20
4
Furosemide3.0%18
5
Milrinone-lactate3.0%18
6
Prednisone2.7%16
7
Tacrolimus2.5%15
8
Epinephrine2.5%15
9
Labetalol-hydrochloride2.5%15
10
Digoxin2.5%15
11
Basiliximab2.4%14
12
Mycophenolate2.4%14
13
Methylprednisolone2.4%14
14
Amlodipine2.4%14
15
Dobutamine-hydrochloride2.0%12

Taken alongside

1
Heparin33.8%200
2
Furosemide32.6%193
3
Nitroglycerin26.2%155
4
Midazolam22.8%135
5
Fentanyl20.8%123
6
Protamine-sulfate20.6%122
7
Metoprolol19.6%116
8
Cefazolin-sodium17.7%105
9
Vancomycin17.1%101
10
Insulin16.7%99
11
Dopamine-hydrochloride16.6%98
12
Potassium-chloride15.9%94
13
Epinephrine14.4%85
14
Acetaminophen13.9%82
15
Amiodarone-hydrochloride13.7%81

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports sodium nitroprusside side effects

43.4% of sodium nitroprusside adverse event reports involve female patients and 45.9% involve male patients. The largest age group is adult at 51%. These figures reflect who reports side effects, not underlying risk.

Sex

Female43.4%
Male45.9%
Unknown10.6%

Age group

< 25.5%
2–115.3%
12–174.9%
18–6450.5%
65+33.8%

What is sodium nitroprusside used for

Conditions and purposes for which patients were taking sodium nitroprusside when the adverse event was reported.

Acute Myocardial InfarctionAortic StenosisAortic Valve IncompetenceArterial StenosisArteriospasm CoronaryBlood PressureBlood Pressure AbnormalBlood Pressure DecreasedBlood Pressure FluctuationBlood Pressure IncreasedBlood Pressure ManagementBlood Pressure Systolic AbnormalBlood Pressure Systolic IncreasedBlood Pressure DecreasedBlood Pressure Fluctuation

Showing 15 of 82 indications

Sodium Nitroprusside brand names and reporting trend

Sodium Nitroprusside is sold under the brand name Nipride Rtu In Sodium Chloride 0.9%.

Brand names

Nipride Rtu In Sodium Chloride 0.9%418

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking sodium nitroprusside with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.