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Sodium Iodide I-131 Side Effects

The most commonly reported side effects of sodium iodide i-131 include hypothyroidism, hypothyroidism, and nausea, based on 2,370 FDA adverse event reports from 2004 to 2025. 2.1% of reports found the drug to be ineffective.

Sodium Iodide I-131 side effects

Percentages show how often each reaction appears relative to total reports for sodium iodide i-131.

1
Hypothyroidism25.3%600
2
Hypothyroidism12.9%305
3
Nausea3.0%70
4
Vomiting2.7%65
5
Diarrhoea2.5%60
6
Off Label Use2.3%55
7
Pyrexia2.3%54
8
Abdominal Pain2.3%54
9
Pneumonia2.2%51
10
Drug Ineffective2.1%49
11
Endocrine Ophthalmopathy2.0%47
12
Fatigue1.9%44
13
Dyspnoea1.4%34
14
Decreased Appetite1.4%34
15
Pain1.4%33

These are voluntary reports and do not establish that sodium iodide i-131 caused these reactions.

Report severity

94.9%Serious2,249 reports
22.2%Hospitalizations526 reports
8.4%Fatal199 reports

Seriousness is determined by the reporter, not by OpenClaim.

Sodium Iodide I-131 drug interactions

Other drugs that appear in adverse event reports alongside sodium iodide i-131. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Atezolizumab0.9%22
2
Bevacizumab0.8%19
3
Nivolumab0.8%19
4
Teduglutide0.8%19
5
Lenalidomide0.8%18
6
Carboplatin0.8%18
7
Paclitaxel0.8%18
8
Aspirin0.8%18
9
Pembrolizumab0.7%17
10
Azacitidine0.7%16
11
Prednisone0.6%15
12
Lenvatinib-mesylate0.6%15
13
Potassium-chloride0.6%15
14
Adalimumab0.6%14
15
Cisplatin0.5%13

Taken alongside

1
Acetaminophen7.6%180
2
Omeprazole5.5%131
3
Levothyroxine-sodium4.4%105
4
Furosemide4.3%102
5
Amlodipine3.8%89
6
Magnesium-oxide3.7%87
7
Pantoprazole-sodium3.5%83
8
Aspirin3.2%77
9
Ergocalciferol3.2%75
10
Lansoprazole2.7%65
11
Sodium-chloride2.7%65
12
Atorvastatin-calcium2.7%64
13
Loperamide-hydrochloride2.6%61
14
Ondansetron2.5%60
15
Prednisolone2.5%59

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports sodium iodide i-131 side effects

48.8% of sodium iodide i-131 adverse event reports involve female patients and 24.8% involve male patients. The largest age group is adult at 59%. These figures reflect who reports side effects, not underlying risk.

Sex

Female48.8%
Male24.8%
Unknown26.5%

Age group

< 23.0%
2–113.7%
12–172.8%
18–6458.5%
65+31.9%

What is sodium iodide i-131 used for

Conditions and purposes for which patients were taking sodium iodide i-131 when the adverse event was reported.

Abdominal DiscomfortAbdominal DistensionAbdominal PainAbdominal Pain UpperAdjuvant TherapyAnaplastic AstrocytomaAngina PectorisAnorexiaAbdominal DistensionAbdominal PainAbdominal Pain UpperAcute Myeloid LeukaemiaAnaemiaAntitussive TherapyBasedow's Disease

Showing 15 of 168 indications

Sodium Iodide I-131 brand names and reporting trend

Sodium Iodide I-131 is sold under the brand name Sodium Iodide I 131.

Brand names

Sodium Iodide I 131867

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking sodium iodide i-131 with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.