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Sodium Fluoride Side Effects

The most commonly reported side effects of sodium fluoride include nausea, pyrexia, and vomiting, based on 2,083 FDA adverse event reports from 2004 to 2025.

Sodium Fluoride side effects

Percentages show how often each reaction appears relative to total reports for sodium fluoride.

1
Nausea9.0%188
2
Pyrexia8.4%175
3
Vomiting8.4%175
4
Fatigue7.9%165
5
Nasopharyngitis7.5%157
6
Pain7.5%157
7
Weight Increased7.4%155
8
Weight Decreased7.4%154
9
Type 2 Diabetes Mellitus7.1%148
10
Diarrhoea7.1%147
11
Peripheral Swelling7.0%146
12
Hypersensitivity6.9%143
13
Urticaria6.9%143
14
Pneumonia6.8%142
15
Dizziness6.8%142

These are voluntary reports and do not establish that sodium fluoride caused these reactions.

Report severity

59.0%Serious1,230 reports
22.2%Hospitalizations463 reports
17.5%Fatal365 reports

Seriousness is determined by the reporter, not by OpenClaim.

Sodium Fluoride drug interactions

Other drugs that appear in adverse event reports alongside sodium fluoride. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Triclosan48.0%1,000
2
Abatacept13.1%272
3
Prednisone12.3%257
4
Acetaminophen12.1%253
5
Alendronate-sodium12.1%252
6
Calcium12.0%250
7
Cetirizine-hydrochloride12.0%250
8
Quetiapine-fumarate11.9%247
9
Celecoxib11.9%247
10
Mycophenolate11.8%246
11
Methotrexate11.8%245
12
Adalimumab11.8%245
13
Diclofenac11.6%242
14
Pregabalin11.6%241
15
Triamcinolone11.5%239

Taken alongside

1
Ergocalciferol13.0%271
2
Acetaminophen12.9%269
3
Aspirin9.9%206
4
Omeprazole8.2%171
5
Pantoprazole-sodium8.0%167
6
Albuterol7.3%153
7
Levothyroxine-sodium6.8%142
8
Chlorhexidine-gluconate6.4%133
9
Prednisone6.3%132
10
Folic-acid6.0%125
11
Metoprolol5.9%123
12
Acyclovir5.9%123
13
Oxycodone5.8%121
14
Lisinopril5.8%121
15
Cetirizine-hydrochloride5.7%119

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports sodium fluoride side effects

59.8% of sodium fluoride adverse event reports involve female patients and 30.1% involve male patients. The largest age group is adult at 53%. These figures reflect who reports side effects, not underlying risk.

Sex

Female59.8%
Male30.1%
Unknown10.1%

Age group

< 21.1%
2–116.2%
12–172.7%
18–6453.1%
65+37.0%

What is sodium fluoride used for

Conditions and purposes for which patients were taking sodium fluoride when the adverse event was reported.

AcneBack PainBreath OdourCompleted SuicideDental CareDental CariesDental CleaningDental Disorder ProphylaxisDental Fluoride TherapyDental PlaqueDental TreatmentDrug Use For Unknown IndicationDry MouthDental CareDental Caries

Showing 15 of 64 indications

Sodium Fluoride brand names and reporting trend

Sodium Fluoride is sold under the brand name Colgate Total.

Brand names

Colgate Total1,518

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking sodium fluoride with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.