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Sodium Chloride Side Effects

The most commonly reported side effects of sodium chloride include nausea, death, and dyspnoea, based on 130,747 FDA adverse event reports from 2004 to 2025. 2.2% of reports found the drug to be ineffective.

Sodium Chloride side effects

Percentages show how often each reaction appears relative to total reports for sodium chloride.

1
Nausea4.7%6,101
2
Death4.3%5,624
3
Dyspnoea3.8%5,026
4
Vomiting3.7%4,789
5
Off Label Use3.7%4,782
6
Myelosuppression3.7%4,781
7
Pyrexia3.4%4,491
8
Headache3.4%4,451
9
Fatigue3.2%4,214
10
Diarrhoea3.2%4,121
11
Death3.0%3,899
12
Pneumonia2.7%3,575
13
Pain2.5%3,287
14
Drug Ineffective2.2%2,868
15
White Blood Cell Count Decreased2.2%2,855

These are voluntary reports and do not establish that sodium chloride caused these reactions.

Report severity

83.4%Serious109,091 reports
44.7%Hospitalizations58,419 reports
18.2%Fatal23,847 reports

Seriousness is determined by the reporter, not by OpenClaim.

Sodium Chloride drug interactions

Other drugs that appear in adverse event reports alongside sodium chloride. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Calcium-chloride32.4%42,409
2
Dextrose32.4%42,306
3
Magnesium-chloride32.3%42,190
4
Sodium-lactate30.9%40,361
5
Potassium-chloride5.2%6,835
6
Icodextrin4.5%5,839
7
Cyclophosphamide3.7%4,812
8
Treprostinil2.5%3,315
9
Polyethylene-glycol-33502.5%3,301
10
Ivacaftor2.3%2,988
11
Ascorbic-acid2.0%2,579
12
Paclitaxel1.9%2,431
13
Sodium-sulfate1.7%2,271
14
Sodium-ascorbate1.7%2,199
15
Docetaxel1.6%2,080

Taken alongside

1
Acetaminophen16.5%21,551
2
Albuterol11.4%14,915
3
Diphenhydramine10.9%14,258
4
Potassium-chloride10.5%13,754
5
Epinephrine10.1%13,201
6
Ergocalciferol8.8%11,538
7
Ondansetron8.2%10,716
8
Omeprazole7.4%9,639
9
Furosemide7.3%9,554
10
Aspirin7.3%9,482
11
Fluticasone7.0%9,202
12
Heparin6.8%8,852
13
Lidocaine6.5%8,491
14
Pantoprazole-sodium6.0%7,795
15
Levothyroxine-sodium5.5%7,167

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports sodium chloride side effects

49.6% of sodium chloride adverse event reports involve female patients and 42.5% involve male patients. The largest age group is adult at 54%. These figures reflect who reports side effects, not underlying risk.

Sex

Female49.6%
Male42.5%
Unknown7.9%

Age group

< 21.8%
2–114.1%
12–173.0%
18–6454.0%
65+37.1%

What is sodium chloride used for

Conditions and purposes for which patients were taking sodium chloride when the adverse event was reported.

21-hydroxylase DeficiencyAbdominal DiscomfortAbdominal DistensionAbdominal InfectionAbdominal PainAbdominal Pain UpperAbortion InducedAbortion MissedAbortion ThreatenedAbscessAbscess LimbAccidental ExposureAccidental Exposure To ProductAcidosisAcinetobacter Infection

Showing 15 of 2,593 indications

Sodium Chloride brand names and reporting trend

Sodium Chloride is sold under the brand name Sodium Chloride In Plastic Container.

Brand names

Sodium Chloride In Plastic Container111,011

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking sodium chloride with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.