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Sitagliptin Side Effects

The most commonly reported side effects of sitagliptin include blood glucose increased, diarrhoea, and nausea, based on 95,765 FDA adverse event reports from 2004 to 2025. 3.9% of reports found the drug to be ineffective.

Sitagliptin side effects

Percentages show how often each reaction appears relative to total reports for sitagliptin.

1
Blood Glucose Increased5.0%4,795
2
Diarrhoea4.5%4,340
3
Nausea4.4%4,179
4
Drug Ineffective3.9%3,769
5
Fatigue3.6%3,485
6
Acute Kidney Injury3.3%3,113
7
Vomiting2.9%2,813
8
Dyspnoea2.8%2,641
9
Death2.7%2,611
10
Dizziness2.7%2,601
11
Headache2.6%2,475
12
Asthenia2.5%2,383
13
Weight Decreased2.4%2,257
14
Off Label Use2.3%2,211
15
Malaise2.3%2,186

These are voluntary reports and do not establish that sitagliptin caused these reactions.

Report severity

65.5%Serious62,747 reports
34.9%Hospitalizations33,423 reports
9.3%Fatal8,902 reports

Seriousness is determined by the reporter, not by OpenClaim.

Sitagliptin drug interactions

Other drugs that appear in adverse event reports alongside sitagliptin. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Metformin17.3%16,525
2
Insulin3.4%3,271
3
Lenalidomide2.3%2,162
4
Exenatide-synthetic2.1%2,051
5
Omeprazole1.9%1,840
6
Hydrochlorothiazide1.9%1,777
7
Empagliflozin1.7%1,645
8
Adalimumab1.7%1,629
9
Esomeprazole1.6%1,560
10
Atorvastatin-calcium1.6%1,535
11
Aspirin1.6%1,503
12
Pioglitazone-hydrochloride1.5%1,447
13
Amlodipine1.5%1,432
14
Canagliflozin1.4%1,302
15
Dulaglutide1.4%1,299

Taken alongside

1
Metformin34.8%33,363
2
Insulin14.0%13,430
3
Aspirin13.9%13,340
4
Atorvastatin-calcium12.8%12,278
5
Amlodipine9.8%9,393
6
Furosemide8.4%8,038
7
Levothyroxine-sodium8.3%7,939
8
Lisinopril8.0%7,663
9
Acetaminophen7.9%7,560
10
Metoprolol7.7%7,405
11
Hydrochlorothiazide7.7%7,404
12
Simvastatin7.2%6,880
13
Ergocalciferol7.0%6,676
14
Glimepiride6.9%6,644
15
Omeprazole6.8%6,479

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports sitagliptin side effects

47.0% of sitagliptin adverse event reports involve female patients and 44.4% involve male patients. The largest age group is elderly at 58%. These figures reflect who reports side effects, not underlying risk.

Sex

Female47.0%
Male44.4%
Unknown8.6%

Age group

< 20.1%
2–11<0.1%
12–17<0.1%
18–6442.0%
65+57.7%

What is sitagliptin used for

Conditions and purposes for which patients were taking sitagliptin when the adverse event was reported.

Abdominal DiscomfortAbdominal Pain UpperAccidental Drug Intake By ChildAccidental Exposure To ProductAcute Kidney InjuryAdjuvant TherapyAdverse Drug ReactionAdverse EventAlbright^s DiseaseAnalgesic TherapyAnticoagulant TherapyAntiplatelet TherapyAnxietyAplastic AnaemiaArthralgia

Showing 15 of 398 indications

Sitagliptin brand names and reporting trend

Sitagliptin is sold under brand names including Zituvio, Steglujan, Sitagliptin And Metformin Hydrochloride.

Brand names

Zituvio11,204
Steglujan3,353
Sitagliptin And Metformin Hydrochloride778

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking sitagliptin with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.