OpenClaim

Silver Side Effects

The most commonly reported side effects of silver include off label use, fatigue, and pain, based on 2,705 FDA adverse event reports from 2004 to 2025. 4.8% of reports found the drug to be ineffective.

Silver side effects

Percentages show how often each reaction appears relative to total reports for silver.

1
Off Label Use6.2%167
2
Fatigue5.7%154
3
Pain5.6%152
4
Product Use In Unapproved Indication5.4%146
5
Death5.3%143
6
Drug Ineffective4.8%130
7
Nausea4.7%128
8
Diarrhoea4.6%124
9
Chronic Kidney Disease4.3%116
10
Acute Kidney Injury3.7%99
11
Rash3.6%97
12
Pneumonia3.6%97
13
Drug Hypersensitivity3.5%95
14
Dyspnoea3.3%89
15
Anxiety3.2%86

These are voluntary reports and do not establish that silver caused these reactions.

Report severity

65.1%Serious1,760 reports
33.6%Hospitalizations909 reports
12.8%Fatal346 reports

Seriousness is determined by the reporter, not by OpenClaim.

Silver drug interactions

Other drugs that appear in adverse event reports alongside silver. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Lenalidomide4.6%124
2
Omeprazole4.4%119
3
Sodium-oxybate3.5%94
4
Esomeprazole3.0%81
5
Lansoprazole3.0%80
6
Pantoprazole-sodium2.7%72
7
Dupilumab2.7%72
8
Acetaminophen2.4%66
9
Ciprofloxacin2.0%53
10
Etanercept1.9%51
11
Amoxicillin1.7%47
12
Rituximab1.7%45
13
Furosemide1.7%45
14
Lorazepam1.6%44
15
Aspirin1.6%44

Taken alongside

1
Acetaminophen32.0%866
2
Aspirin20.1%543
3
Ergocalciferol19.9%539
4
Furosemide19.9%537
5
Albuterol19.2%520
6
Gabapentin18.7%505
7
Ondansetron16.0%433
8
Prednisone15.0%406
9
Omeprazole14.9%402
10
Oxycodone14.8%400
11
Metoprolol14.1%382
12
Fluticasone13.8%374
13
Pantoprazole-sodium13.6%367
14
Levothyroxine-sodium13.4%362
15
Atorvastatin-calcium12.6%342

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports silver side effects

54.2% of silver adverse event reports involve female patients and 38.7% involve male patients. The largest age group is adult at 53%. These figures reflect who reports side effects, not underlying risk.

Sex

Female54.2%
Male38.7%
Unknown7.1%

Age group

< 20.9%
2–111.5%
12–171.5%
18–6453.2%
65+42.9%

What is silver used for

Conditions and purposes for which patients were taking silver when the adverse event was reported.

Accident At WorkAdverse EventAnaemiaAnorectal DisorderAntibacterial ProphylaxisAntibiotic LevelAntibiotic TherapyArthropod StingAdverse EventAnimal BiteAntibiotic TherapyArthritisArthropod BiteAtrial FibrillationBacterial Infection

Showing 15 of 240 indications

Silver brand names and reporting trend

Silver is sold under the brand name Thermazene.

Brand names

Thermazene1,702

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking silver with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.