The most commonly reported side effects of siltuximab include off label use, cytokine release syndrome, and immune effector cell-associated neurotoxicity syndrome, based on 582 FDA adverse event reports from 2013 to 2025. 15.8% of reports found the drug to be ineffective.
Percentages show how often each reaction appears relative to total reports for siltuximab.
These are voluntary reports and do not establish that siltuximab caused these reactions.
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Other drugs that appear in adverse event reports alongside siltuximab. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.
Also suspected
Taken alongside
Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.
25.3% of siltuximab adverse event reports involve female patients and 31.6% involve male patients. The largest age group is adult at 49%. These figures reflect who reports side effects, not underlying risk.
Sex
Age group
Conditions and purposes for which patients were taking siltuximab when the adverse event was reported.
Showing 15 of 65 indications
Siltuximab is sold under the brand name Sylvant.
An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.
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