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Sevoflurane Side Effects

The most commonly reported side effects of sevoflurane include hypotension, drug interaction, and hyperthermia malignant, based on 8,455 FDA adverse event reports from 2004 to 2025. 3.0% of reports found the drug to be ineffective.

Sevoflurane side effects

Percentages show how often each reaction appears relative to total reports for sevoflurane.

1
Hypotension5.5%465
2
Drug Interaction4.5%378
3
Hyperthermia Malignant3.6%305
4
Anaesthetic Complication Neurological3.2%271
5
Cardiac Arrest3.2%270
6
Drug Ineffective3.0%255
7
Bradycardia2.9%244
8
Serotonin Syndrome2.8%236
9
Acute Kidney Injury2.6%224
10
Tachycardia2.6%223
11
Off Label Use2.4%206
12
Foetal Exposure During Pregnancy2.4%202
13
Anaphylactic Shock2.3%197
14
Anaphylactic Reaction2.2%183
15
Oxygen Saturation Decreased1.9%164

These are voluntary reports and do not establish that sevoflurane caused these reactions.

Report severity

94.8%Serious8,018 reports
33.6%Hospitalizations2,844 reports
6.9%Fatal583 reports

Seriousness is determined by the reporter, not by OpenClaim.

Sevoflurane drug interactions

Other drugs that appear in adverse event reports alongside sevoflurane. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Propofol30.5%2,583
2
Fentanyl20.1%1,699
3
Rocuronium-bromide13.7%1,157
4
Remifentanil-hydrochloride10.5%889
5
Midazolam8.7%735
6
Sufentanil-citrate6.5%552
7
Lidocaine6.1%515
8
Ketamine-hydrochloride5.5%461
9
Acetaminophen5.0%422
10
Ondansetron4.6%392
11
Dexamethasone4.6%385
12
Epinephrine4.0%337
13
Atracurium-besylate3.7%312
14
Succinylcholine-chloride3.5%295
15
Sugammadex3.4%286

Taken alongside

1
Propofol25.8%2,182
2
Fentanyl22.1%1,872
3
Midazolam14.2%1,197
4
Rocuronium-bromide13.3%1,122
5
Remifentanil-hydrochloride10.0%842
6
Lidocaine8.0%675
7
Oxygen7.9%668
8
Acetaminophen6.5%547
9
Dexamethasone5.6%473
10
Nitrous-oxide4.9%417
11
Ondansetron4.7%396
12
Vecuronium-bromide4.6%393
13
Cefazolin-sodium4.5%382
14
Epinephrine4.1%345
15
Atropine3.9%329

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports sevoflurane side effects

38.1% of sevoflurane adverse event reports involve female patients and 37.4% involve male patients. The largest age group is adult at 52%. These figures reflect who reports side effects, not underlying risk.

Sex

Female38.1%
Male37.4%
Unknown24.6%

Age group

< 29.4%
2–1112.8%
12–176.9%
18–6451.5%
65+19.4%

What is sevoflurane used for

Conditions and purposes for which patients were taking sevoflurane when the adverse event was reported.

Abdominal OperationAccidental ExposureAccidental Exposure To ProductAccidental OverdoseAdenoidectomyAdenotonsillectomyAdhesiolysisAnaesthesiaAnaesthesia ProcedureAnaesthetic PremedicationAnalgesic EffectAnalgesic Intervention Supportive TherapyAnalgesic TherapyAnaphylactic ReactionAnesthesia

Showing 15 of 309 indications

Sevoflurane brand names and reporting trend

Sevoflurane is sold under the brand name Sojourn.

Brand names

Sojourn9,275

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking sevoflurane with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.