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Sevelamer Side Effects

The most commonly reported side effects of sevelamer include constipation, diarrhoea, and pruritus, based on 19,668 FDA adverse event reports from 2004 to 2025.

Sevelamer side effects

Percentages show how often each reaction appears relative to total reports for sevelamer.

1
Constipation13.4%2,641
2
Diarrhoea6.3%1,239
3
Pruritus5.6%1,094
4
Nausea5.0%981
5
Renal Failure4.8%951
6
Chronic Kidney Disease4.8%935
7
End Stage Renal Disease4.7%918
8
Death4.3%848
9
Acute Kidney Injury3.8%743
10
Vomiting3.3%657
11
Dyspnoea2.3%457
12
Off Label Use2.1%414
13
Nephrogenic Anaemia2.1%405
14
Abdominal Pain2.0%395
15
Fatigue1.9%374

These are voluntary reports and do not establish that sevelamer caused these reactions.

Report severity

65.7%Serious12,930 reports
36.9%Hospitalizations7,250 reports
14.3%Fatal2,819 reports

Seriousness is determined by the reporter, not by OpenClaim.

Sevelamer drug interactions

Other drugs that appear in adverse event reports alongside sevelamer. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Dextrose4.0%780
2
Esomeprazole3.9%760
3
Cinacalcet-hydrochloride3.8%745
4
Omeprazole3.7%729
5
Lenalidomide3.5%686
6
Patiromer-sorbitex-calcium3.4%677
7
Pantoprazole-sodium3.0%599
8
Sodium-chloride2.9%565
9
Magnesium-chloride2.6%518
10
Lansoprazole2.6%518
11
Calcium-chloride2.6%507
12
Sodium-lactate2.6%506
13
Paricalcitol2.0%401
14
Darbepoetin-alfa1.9%373
15
Gadopentetate-dimeglumine1.8%350

Taken alongside

1
Aspirin17.5%3,437
2
Amlodipine16.2%3,190
3
Acetaminophen14.0%2,763
4
Furosemide14.0%2,760
5
Metoprolol13.2%2,594
6
Insulin13.1%2,575
7
Atorvastatin-calcium11.5%2,260
8
Carvedilol10.4%2,047
9
Cinacalcet-hydrochloride9.6%1,894
10
Pantoprazole-sodium9.3%1,822
11
Omeprazole8.8%1,725
12
Calcitriol8.7%1,720
13
Gabapentin8.7%1,709
14
Ergocalciferol8.6%1,694
15
Levothyroxine-sodium8.4%1,654

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports sevelamer side effects

35.1% of sevelamer adverse event reports involve female patients and 39.8% involve male patients. The largest age group is adult at 67%. These figures reflect who reports side effects, not underlying risk.

Sex

Female35.1%
Male39.8%
Unknown25.1%

Age group

< 20.2%
2–111.0%
12–170.8%
18–6467.3%
65+30.6%

What is sevelamer used for

Conditions and purposes for which patients were taking sevelamer when the adverse event was reported.

Acute Kidney InjuryAdverse EventAnti-glomerular Basement Membrane DiseaseAortic Valve StenosisAzotaemiaAcute Kidney InjuryAcute Monocytic LeukaemiaAdverse EventAnti-glomerular Basement Membrane DiseaseAnti-neutrophil Cytoplasmic Antibody Positive VasculitisArteriovenous MalformationAzotaemiaBlood CalciumBlood Calcium AbnormalBlood Calcium Decreased

Showing 15 of 200 indications

Sevelamer brand names and reporting trend

Sevelamer is sold under the brand name Sevelamer Carbonate.

Brand names

Sevelamer Carbonate1,969

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking sevelamer with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.