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Sermorelin Side Effects

The most commonly reported side effects of sermorelin include pruritus, hypersensitivity, and malaise, based on 48 FDA adverse event reports from 2009 to 2025.

Sermorelin side effects

Percentages show how often each reaction appears relative to total reports for sermorelin.

1
Pruritus8.3%4
2
Hypersensitivity8.3%4
3
Malaise6.3%3
4
Swelling6.3%3
5
Nausea6.3%3
6
Rash6.3%3
7
Anaphylactic Reaction6.3%3
8
Erythema6.3%3
9
Pain In Extremity4.2%2
10
Arthralgia4.2%2
11
Hyperhidrosis4.2%2
12
Insomnia4.2%2
13
Infection4.2%2
14
Wrong Technique In Product Usage Process4.2%2
15
Burning Sensation4.2%2

These are voluntary reports and do not establish that sermorelin caused these reactions.

Report severity

58.3%Serious28 reports
14.6%Hospitalizations7 reports
2.1%Fatal1 reports

Seriousness is determined by the reporter, not by OpenClaim.

Sermorelin drug interactions

Other drugs that appear in adverse event reports alongside sermorelin. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Sodium-oxybate27.1%13
2
Lenalidomide8.3%4
3
Tirzepatide8.3%4
4
Sterile4.2%2
5
Estradiol2.1%1
6
Teriparatide2.1%1
7
Tadalafil2.1%1
8
Sulfamethoxazole2.1%1
9
Trimethoprim2.1%1
10
Pomalidomide2.1%1
11
Abiraterone-acetate2.1%1
12
Ketorolac-tromethamine2.1%1
13
Testosterone2.1%1
14
Calcium-oxybate2.1%1
15
Magnesium-oxybate2.1%1

Taken alongside

1
Ergocalciferol33.3%16
2
Testosterone29.2%14
3
Fish22.9%11
4
Tramadol-hydrochloride12.5%6
5
Amlodipine12.5%6
6
Progesterone10.4%5
7
Ascorbic-acid10.4%5
8
Epinephrine8.3%4
9
Liothyronine-sodium8.3%4
10
Trazodone-hydrochloride8.3%4
11
Zolpidem-tartrate8.3%4
12
Acetaminophen8.3%4
13
Levothyroxine-sodium8.3%4
14
Methocarbamol8.3%4
15
Atenolol8.3%4

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports sermorelin side effects

45.8% of sermorelin adverse event reports involve female patients and 52.1% involve male patients. The largest age group is adult at 86%. These figures reflect who reports side effects, not underlying risk.

Sex

Female45.8%
Male52.1%
Unknown2.1%

Age group

< 20.0%
2–110.0%
12–170.0%
18–6485.7%
65+14.3%

What is sermorelin used for

Conditions and purposes for which patients were taking sermorelin when the adverse event was reported.

ArthralgiaBenign Prostatic HyperplasiaBlood Growth Hormone AbnormalBlood Growth Hormone DecreasedGrowth Hormone DeficiencyHormone Replacement TherapyMuscle DisorderPostoperative CareProduct Used For Unknown IndicationPainProduct Used For Unknown IndicationSkin DisorderWeight Decreased

Sermorelin brand names and reporting trend

Sermorelin is sold under the brand name Geref.

Brand names

Geref52

Quarterly reports (20092025)

2016202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking sermorelin with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.