The most commonly reported side effects of semaglutide include nausea, vomiting, and off label use, based on 78,681 FDA adverse event reports from 2004 to 2025.
Percentages show how often each reaction appears relative to total reports for semaglutide.
These are voluntary reports and do not establish that semaglutide caused these reactions.
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Other drugs that appear in adverse event reports alongside semaglutide. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.
Also suspected
Taken alongside
Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.
60.2% of semaglutide adverse event reports involve female patients and 31.0% involve male patients. The largest age group is adult at 65%. These figures reflect who reports side effects, not underlying risk.
Sex
Age group
Conditions and purposes for which patients were taking semaglutide when the adverse event was reported.
Showing 15 of 419 indications
Semaglutide is sold under the brand name Rybelsus.
An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.
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