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Selinexor Side Effects

The most commonly reported side effects of selinexor include nausea, fatigue, and decreased appetite, based on 8,163 FDA adverse event reports from 2006 to 2025. 4.9% of reports found the drug to be ineffective.

Selinexor side effects

Percentages show how often each reaction appears relative to total reports for selinexor.

1
Nausea30.6%2,499
2
Fatigue23.0%1,881
3
Decreased Appetite16.4%1,340
4
Diarrhoea15.5%1,263
5
Plasma Cell Myeloma14.0%1,143
6
Vomiting11.0%900
7
Asthenia10.3%837
8
Death9.9%811
9
Thrombocytopenia8.9%723
10
Platelet Count Decreased7.9%647
11
Weight Decreased7.7%630
12
Off Label Use5.8%472
13
Pneumonia5.6%458
14
Anaemia5.6%457
15
Dizziness5.4%440

These are voluntary reports and do not establish that selinexor caused these reactions.

Report severity

54.8%Serious4,470 reports
31.0%Hospitalizations2,534 reports
16.8%Fatal1,374 reports

Seriousness is determined by the reporter, not by OpenClaim.

Selinexor drug interactions

Other drugs that appear in adverse event reports alongside selinexor. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Dexamethasone13.1%1,069
2
Bortezomib8.5%690
3
Pomalidomide7.0%572
4
Lenalidomide4.5%366
5
Carfilzomib3.5%285
6
Cyclophosphamide3.3%273
7
Daratumumab2.3%191
8
Doxorubicin-hydrochloride1.8%148
9
Rituximab1.8%147
10
Vincristine-sulfate1.2%94
11
Ixazomib-citrate1.1%91
12
Venetoclax1.1%87
13
Etoposide0.9%72
14
Gemcitabine0.8%68
15
Cisplatin0.8%67

Taken alongside

1
Dexamethasone43.1%3,520
2
Ondansetron34.8%2,844
3
Acyclovir27.0%2,207
4
Olanzapine13.8%1,124
5
Prochlorperazine11.4%927
6
Aspirin10.7%877
7
Bortezomib10.0%818
8
Acetaminophen9.4%764
9
Gabapentin8.5%690
10
Pantoprazole-sodium8.1%663
11
Oxycodone8.0%657
12
Pomalidomide7.8%634
13
Omeprazole7.6%617
14
Amlodipine7.3%596
15
Metoprolol7.3%594

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports selinexor side effects

16.3% of selinexor adverse event reports involve female patients and 19.6% involve male patients. The largest age group is elderly at 53%. These figures reflect who reports side effects, not underlying risk.

Sex

Female16.3%
Male19.6%
Unknown64.1%

Age group

< 20.2%
2–110.9%
12–170.3%
18–6445.3%
65+53.3%

What is selinexor used for

Conditions and purposes for which patients were taking selinexor when the adverse event was reported.

Abdominal DiscomfortAbdominal Pain UpperAcute Lymphocytic LeukaemiaAcute Myeloid LeukaemiaAdenocarcinoma Of ColonAdenoid Cystic CarcinomaAnaplastic Large Cell Lymphoma T- And Null-cell TypesAngiocentric LymphomaAngioimmunoblastic T-cell Lymphoma Stage IiiAcute LeukaemiaAcute Lymphocytic LeukaemiaAcute Lymphocytic Leukaemia RecurrentAcute Megakaryocytic LeukaemiaAcute Myeloid LeukaemiaAcute Myeloid Leukaemia Refractory

Showing 15 of 242 indications

Selinexor brand names and reporting trend

Selinexor is sold under the brand name Xpovio.

Brand names

Xpovio4,849

Quarterly reports (20062025)

2010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking selinexor with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.