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Selexipag Side Effects

The most commonly reported side effects of selexipag include headache, diarrhoea, and dyspnoea, based on 24,884 FDA adverse event reports from 2013 to 2025.

Selexipag side effects

Percentages show how often each reaction appears relative to total reports for selexipag.

1
Headache26.5%6,592
2
Diarrhoea20.4%5,068
3
Dyspnoea18.7%4,656
4
Nausea16.2%4,020
5
Fatigue10.1%2,519
6
Death10.0%2,490
7
Pain In Jaw9.6%2,377
8
Dizziness9.0%2,251
9
Pain8.7%2,170
10
Pain In Extremity8.3%2,076
11
Myalgia7.8%1,948
12
Vomiting7.7%1,906
13
Pneumonia7.1%1,771
14
Malaise7.1%1,771
15
Hypotension6.8%1,680

These are voluntary reports and do not establish that selexipag caused these reactions.

Report severity

75.2%Serious18,713 reports
49.3%Hospitalizations12,274 reports
19.1%Fatal4,742 reports

Seriousness is determined by the reporter, not by OpenClaim.

Selexipag drug interactions

Other drugs that appear in adverse event reports alongside selexipag. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Macitentan25.6%6,378
2
Ambrisentan20.6%5,126
3
Treprostinil11.1%2,756
4
Tadalafil9.3%2,303
5
Riociguat6.5%1,606
6
Bosentan4.1%1,017
7
Sildenafil-citrate3.1%764
8
Epoprostenol-sodium2.9%714
9
Acetaminophen2.1%521
10
Sotatercept-csrk1.1%262
11
Furosemide0.6%161
12
Iloprost0.5%136
13
Warfarin0.4%109
14
Loperamide-hydrochloride0.4%95
15
Spironolactone0.3%86

Taken alongside

1
Tadalafil24.0%5,984
2
Sildenafil-citrate16.9%4,207
3
Macitentan11.7%2,912
4
Furosemide11.2%2,776
5
Ambrisentan10.4%2,600
6
Riociguat8.9%2,205
7
Warfarin8.8%2,191
8
Spironolactone7.6%1,887
9
Apixaban6.2%1,541
10
Oxygen6.1%1,519
11
Amlodipine4.9%1,218
12
Treprostinil4.1%1,031
13
Aspirin4.0%995
14
Acetaminophen3.9%965
15
Levothyroxine-sodium3.6%900

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports selexipag side effects

70.5% of selexipag adverse event reports involve female patients and 25.2% involve male patients. The largest age group is adult at 52%. These figures reflect who reports side effects, not underlying risk.

Sex

Female70.5%
Male25.2%
Unknown4.3%

Age group

< 20.4%
2–111.5%
12–171.6%
18–6452.3%
65+44.3%

What is selexipag used for

Conditions and purposes for which patients were taking selexipag when the adverse event was reported.

Anticoagulant TherapyArterial Occlusive DiseaseArteriosclerosisAtrial Septal Defect RepairAccidental Exposure To Product By ChildAdverse Drug ReactionAnticoagulant TherapyAntinuclear AntibodyArthralgiaAtrioventricular Septal DefectAttention Deficit Hyperactivity DisorderBlood Pressure DecreasedBack PainBlood Pressure DecreasedBronchopulmonary Dysplasia

Showing 15 of 112 indications

Selexipag brand names and reporting trend

Selexipag is sold under the brand name Uptravi.

Brand names

Uptravi6,026

Quarterly reports (20132025)

20132016202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking selexipag with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.