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Selegiline Side Effects

The most commonly reported side effects of selegiline include hallucination, fall, and dyskinesia, based on 4,442 FDA adverse event reports from 2004 to 2025. 7.7% of reports found the drug to be ineffective.

Selegiline side effects

Percentages show how often each reaction appears relative to total reports for selegiline.

1
Drug Ineffective7.7%341
2
Hallucination5.5%246
3
Fall4.1%181
4
Dyskinesia3.9%175
5
Dizziness3.6%162
6
Insomnia3.6%161
7
Application Site Erythema3.1%138
8
Tremor3.0%132
9
Drug Interaction2.9%131
10
Fatigue2.7%122
11
Death2.7%121
12
Confusional State2.7%120
13
Anxiety2.7%119
14
Depression2.6%117
15
Parkinson^s Disease2.5%112

These are voluntary reports and do not establish that selegiline caused these reactions.

Report severity

55.6%Serious2,471 reports
26.2%Hospitalizations1,164 reports
7.0%Fatal313 reports

Seriousness is determined by the reporter, not by OpenClaim.

Selegiline drug interactions

Other drugs that appear in adverse event reports alongside selegiline. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Levodopa16.1%713
2
Carbidopa13.3%592
3
Pimavanserin7.1%316
4
Pramipexole-dihydrochloride6.3%279
5
Entacapone5.9%260
6
Ropinirole-hydrochloride5.2%232
7
Amantadine4.9%217
8
Rotigotine2.9%128
9
Sodium-oxybate2.8%126
10
Istradefylline2.3%102
11
Apomorphine-hydrochloride2.1%95
12
Quetiapine-fumarate2.1%92
13
Pergolide-mesylate1.6%73
14
Clonazepam1.4%64
15
Aripiprazole1.3%59

Taken alongside

1
Levodopa26.6%1,181
2
Carbidopa25.4%1,130
3
Amantadine9.5%423
4
Aspirin8.9%397
5
Clonazepam8.6%384
6
Levothyroxine-sodium7.9%352
7
Pramipexole-dihydrochloride7.9%351
8
Entacapone7.7%341
9
Ergocalciferol7.1%317
10
Ropinirole-hydrochloride6.3%282
11
Quetiapine-fumarate6.3%281
12
Acetaminophen6.2%277
13
Atorvastatin-calcium5.4%240
14
Gabapentin4.7%210
15
Omeprazole4.7%209

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports selegiline side effects

47.7% of selegiline adverse event reports involve female patients and 44.1% involve male patients. The largest age group is elderly at 54%. These figures reflect who reports side effects, not underlying risk.

Sex

Female47.7%
Male44.1%
Unknown8.1%

Age group

< 20.2%
2–110.2%
12–170.5%
18–6445.6%
65+53.5%

What is selegiline used for

Conditions and purposes for which patients were taking selegiline when the adverse event was reported.

Abdominal PainAffective DisorderAgitationAgoraphobiaAltered State Of ConsciousnessAnhedoniaAntidepressant TherapyAnxietyAnxiety DisorderAstheniaAttention Deficit/hyperactivity DisorderAntidepressant TherapyAnxietyAnxiety DisorderAromatic L-amino Acid Decarboxylase Deficiency

Showing 15 of 133 indications

Selegiline brand names and reporting trend

Selegiline is sold under brand names including Emsam, Selegiline Hydrochloride.

Brand names

Emsam2,772
Selegiline Hydrochloride43

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking selegiline with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.