OpenClaim

Seladelpar Side Effects

The most commonly reported side effects of seladelpar include pruritus, dizziness, and death, based on 353 FDA adverse event reports from 2015 to 2025. 6.2% of reports found the drug to be ineffective.

Seladelpar side effects

Percentages show how often each reaction appears relative to total reports for seladelpar.

1
Pruritus7.4%26
2
Dizziness6.2%22
3
Drug Ineffective6.2%22
4
Death5.9%21
5
Blood Alkaline Phosphatase Increased5.4%19
6
Fatigue5.1%18
7
Headache4.5%16
8
Nausea3.4%12
9
Diarrhoea3.4%12
10
Abdominal Distension3.4%12
11
Aspartate Aminotransferase Increased3.4%12
12
Abdominal Pain3.1%11
13
Alanine Aminotransferase Increased3.1%11
14
Fall2.8%10
15
Hepatic Enzyme Increased2.8%10

These are voluntary reports and do not establish that seladelpar caused these reactions.

Report severity

62.6%Serious221 reports
22.9%Hospitalizations81 reports
5.9%Fatal21 reports

Seriousness is determined by the reporter, not by OpenClaim.

Seladelpar drug interactions

Other drugs that appear in adverse event reports alongside seladelpar. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Ursodiol0.8%3
2
Obeticholic-acid0.6%2
3
Fenofibrate0.6%2
4
Elafibranor0.6%2
5
Ingenol-mebutate0.3%1
6
Ibuprofen0.3%1
7
Montelukast-sodium0.3%1
8
Tirzepatide0.3%1
9
Heparin0.3%1
10
Albuterol0.3%1
11
Odevixibat0.3%1

Taken alongside

1
Ursodiol10.2%36
2
Taurursodiol3.1%11
3
Ergocalciferol2.8%10
4
Levothyroxine-sodium2.5%9
5
Omeprazole2.3%8
6
Pantoprazole-sodium2.3%8
7
Obeticholic-acid2.0%7
8
Rosuvastatin2.0%7
9
Ascorbic-acid1.7%6
10
Acetaminophen1.4%5
11
Amlodipine1.4%5
12
Atorvastatin-calcium1.4%5
13
Sertraline-hydrochloride1.4%5
14
Aspirin1.1%4
15
Calcium1.1%4

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports seladelpar side effects

85.0% of seladelpar adverse event reports involve female patients and 11.9% involve male patients. The largest age group is adult at 51%. These figures reflect who reports side effects, not underlying risk.

Sex

Female85.0%
Male11.9%
Unknown3.1%

Age group

< 20.7%
2–110.0%
12–170.0%
18–6451.3%
65+48.0%

What is seladelpar used for

Conditions and purposes for which patients were taking seladelpar when the adverse event was reported.

Biliary FibrosisBiliary Tract DisorderCholangitisCholangitis SclerosingOverlap SyndromePrimary Biliary CholangitisProduct Used For Unknown IndicationPruritusRosacea

Seladelpar brand names and reporting trend

Seladelpar is sold under the brand name Livdelzi.

Brand names

Livdelzi198

Quarterly reports (20152025)

20152025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking seladelpar with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.