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Secukinumab Side Effects

The most commonly reported side effects of secukinumab include psoriasis, pain, and arthralgia, based on 157,280 FDA adverse event reports from 2014 to 2025. 18.3% of reports found the drug to be ineffective.

Secukinumab side effects

Percentages show how often each reaction appears relative to total reports for secukinumab.

1
Drug Ineffective18.3%28,726
2
Psoriasis14.4%22,572
3
Pain10.3%16,140
4
Arthralgia9.2%14,490
5
Fatigue6.5%10,192
6
Psoriatic Arthropathy6.2%9,809
7
Pruritus5.8%9,168
8
Malaise5.8%9,103
9
Rash5.5%8,711
10
Condition Aggravated5.2%8,214
11
Diarrhoea4.9%7,681
12
Nasopharyngitis4.8%7,488
13
Pain In Extremity4.5%7,099
14
Headache4.4%6,940
15
Off Label Use4.0%6,358

These are voluntary reports and do not establish that secukinumab caused these reactions.

Report severity

39.5%Serious62,074 reports
13.1%Hospitalizations20,645 reports
4.9%Fatal7,752 reports

Seriousness is determined by the reporter, not by OpenClaim.

Secukinumab drug interactions

Other drugs that appear in adverse event reports alongside secukinumab. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Methotrexate10.1%15,818
2
Adalimumab7.4%11,632
3
Etanercept6.1%9,665
4
Diclofenac5.3%8,267
5
Leflunomide5.2%8,209
6
Infliximab4.6%7,200
7
Sulfasalazine4.2%6,529
8
Rituximab4.1%6,503
9
Golimumab4.1%6,398
10
Abatacept4.1%6,380
11
Certolizumab-pegol4.0%6,358
12
Prednisone3.9%6,119
13
Apremilast3.8%6,025
14
Hydroxychloroquine-sulfate3.7%5,845
15
Folic-acid3.7%5,743

Taken alongside

1
Methotrexate3.8%5,992
2
Sulfasalazine3.1%4,872
3
Acetaminophen3.0%4,725
4
Ibuprofen3.0%4,717
5
Adalimumab2.9%4,622
6
Prednisone2.9%4,489
7
Naproxen2.8%4,458
8
Pantoprazole-sodium2.6%4,022
9
Ergocalciferol2.5%4,001
10
Etanercept2.2%3,503
11
Celecoxib2.1%3,291
12
Lisinopril2.0%3,157
13
Folic-acid2.0%3,120
14
Levothyroxine-sodium1.8%2,807
15
Diclofenac1.7%2,747

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports secukinumab side effects

57.6% of secukinumab adverse event reports involve female patients and 35.2% involve male patients. The largest age group is adult at 81%. These figures reflect who reports side effects, not underlying risk.

Sex

Female57.6%
Male35.2%
Unknown7.2%

Age group

< 20.2%
2–110.1%
12–170.4%
18–6480.6%
65+18.6%

What is secukinumab used for

Conditions and purposes for which patients were taking secukinumab when the adverse event was reported.

Abdominal DiscomfortAcneAcne ConglobataAcquired Immunodeficiency SyndromeActinic KeratosisAcute Generalised Exanthematous PustulosisAcute Respiratory Distress SyndromeAlopeciaAmnesiaAmyloidosisAnaemiaAnal PolypAnaphylactic ReactionAnkyloglossia AcquiredAnkylosing Spondylitis

Showing 15 of 585 indications

Secukinumab brand names and reporting trend

Secukinumab is sold under the brand name Cosentyx.

Brand names

Cosentyx8,103

Quarterly reports (20142025)

20142016202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking secukinumab with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.