OpenClaim

Sebetralstat Side Effects

The most commonly reported side effects of sebetralstat include hereditary angioedema, weight increased, and product dose omission issue, based on 61 FDA adverse event reports from 2025 to 2025. 14.8% of reports found the drug to be ineffective.

Sebetralstat side effects

Percentages show how often each reaction appears relative to total reports for sebetralstat.

1
Hereditary Angioedema41.0%25
2
Drug Ineffective14.8%9
3
Weight Increased9.8%6
4
Product Dose Omission Issue8.2%5
5
Stress8.2%5
6
Headache8.2%5
7
Hypersensitivity6.6%4
8
Incorrect Dosage Administered6.6%4
9
Product Use Issue6.6%4
10
Incorrect Dose Administered6.6%4
11
Vomiting4.9%3
12
Insurance Issue4.9%3
13
Off Label Use4.9%3
14
Anaphylactic Reaction3.3%2
15
Nausea3.3%2

These are voluntary reports and do not establish that sebetralstat caused these reactions.

Report severity

47.5%Serious29 reports
24.6%Hospitalizations15 reports
0.0%Fatal0 reports

Seriousness is determined by the reporter, not by OpenClaim.

Sebetralstat drug interactions

Other drugs that appear in adverse event reports alongside sebetralstat. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Lanadelumab-flyo14.8%9
2
Ecallantide4.9%3
3
Icatibant-acetate4.9%3
4
Garadacimab-gxii4.9%3
5
Diphenhydramine1.6%1
6
Enoxaparin-sodium1.6%1
7
Berotralstat-dihydrochloride1.6%1

Taken alongside

1
Icatibant-acetate26.2%16
2
Epinephrine11.5%7
3
Garadacimab-gxii9.8%6
4
Berotralstat-dihydrochloride8.2%5
5
Sodium-chloride8.2%5
6
Lanadelumab-flyo6.6%4
7
Omalizumab4.9%3
8
Diphenhydramine4.9%3
9
Famotidine4.9%3
10
Ascorbic-acid3.3%2
11
Fexofenadine-hydrochloride3.3%2
12
Omeprazole3.3%2
13
Acetaminophen3.3%2
14
Cetirizine-hydrochloride3.3%2
15
Sterile3.3%2

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports sebetralstat side effects

82.0% of sebetralstat adverse event reports involve female patients and 16.4% involve male patients. The largest age group is adult at 75%. These figures reflect who reports side effects, not underlying risk.

Sex

Female82.0%
Male16.4%
Unknown1.6%

Age group

< 20.0%
2–110.0%
12–173.6%
18–6474.5%
65+21.8%

What is sebetralstat used for

Conditions and purposes for which patients were taking sebetralstat when the adverse event was reported.

Hereditary AngioedemaHereditary Angioedema With Normal C1 Esterase InhibitorHypogammaglobulinaemiaProduct Used For Unknown Indication

Sebetralstat brand names and reporting trend

Sebetralstat is sold under the brand name Ekterly.

Brand names

Ekterly9

Quarterly reports (20252025)

20252025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking sebetralstat with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.