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Saxagliptin Side Effects

The most commonly reported side effects of saxagliptin include blood glucose increased, cardiac failure congestive, and nausea, based on 11,255 FDA adverse event reports from 2006 to 2025. 3.7% of reports found the drug to be ineffective.

Saxagliptin side effects

Percentages show how often each reaction appears relative to total reports for saxagliptin.

1
Blood Glucose Increased4.3%481
2
Cardiac Failure Congestive4.0%451
3
Nausea3.9%444
4
Diarrhoea3.8%429
5
Cardiac Failure3.8%423
6
Drug Ineffective3.7%416
7
Fatigue3.2%364
8
Weight Decreased3.1%352
9
Dizziness2.8%318
10
Death2.5%281
11
Vomiting2.5%276
12
Acute Kidney Injury2.3%263
13
Asthenia2.3%262
14
Off Label Use2.3%259
15
Headache2.3%255

These are voluntary reports and do not establish that saxagliptin caused these reactions.

Report severity

64.3%Serious7,235 reports
32.2%Hospitalizations3,625 reports
7.2%Fatal808 reports

Seriousness is determined by the reporter, not by OpenClaim.

Saxagliptin drug interactions

Other drugs that appear in adverse event reports alongside saxagliptin. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Metformin23.1%2,605
2
Insulin4.6%521
3
Exenatide-synthetic2.6%290
4
Dapagliflozin2.4%275
5
Adalimumab2.2%252
6
Esomeprazole1.9%217
7
Lisinopril1.9%214
8
Lenalidomide1.8%201
9
Omeprazole1.7%196
10
Rosuvastatin1.7%187
11
Pioglitazone-hydrochloride1.5%166
12
Hydrochlorothiazide1.5%165
13
Canagliflozin1.4%155
14
Sitagliptin1.3%143
15
Aspirin1.2%138

Taken alongside

1
Metformin29.7%3,340
2
Aspirin16.6%1,868
3
Insulin12.4%1,393
4
Atorvastatin-calcium10.9%1,230
5
Amlodipine9.4%1,061
6
Furosemide8.7%984
7
Lisinopril8.7%976
8
Hydrochlorothiazide8.0%900
9
Levothyroxine-sodium7.4%836
10
Ergocalciferol7.4%836
11
Acetaminophen7.3%820
12
Simvastatin7.2%809
13
Metoprolol6.6%742
14
Glimepiride6.5%735
15
Rosuvastatin6.3%706

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports saxagliptin side effects

46.7% of saxagliptin adverse event reports involve female patients and 43.4% involve male patients. The largest age group is elderly at 51%. These figures reflect who reports side effects, not underlying risk.

Sex

Female46.7%
Male43.4%
Unknown9.9%

Age group

< 2<0.1%
2–110.1%
12–17<0.1%
18–6448.3%
65+51.4%

What is saxagliptin used for

Conditions and purposes for which patients were taking saxagliptin when the adverse event was reported.

Actinic KeratosisArthritisAngina UnstableArthralgiaBlood Cholesterol AbnormalBlood GlucoseBlood Glucose AbnormalBlood Glucose DecreasedBlood Glucose IncreasedBlood Insulin IncreasedBlood Pressure IncreasedBlood Pressure ManagementBlood Sugar IncreasedBreast CancerBlood Glucose Abnormal

Showing 15 of 87 indications

Saxagliptin brand names and reporting trend

Saxagliptin is sold under the brand name Dapagliflozin And Saxagliptin.

Brand names

Dapagliflozin And Saxagliptin2,040

Quarterly reports (20062025)

20062010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking saxagliptin with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.