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Sarecycline Side Effects

The most commonly reported side effects of sarecycline include headache, dizziness, and vision blurred, based on 182 FDA adverse event reports from 2019 to 2025. 8.2% of reports found the drug to be ineffective.

Sarecycline side effects

Percentages show how often each reaction appears relative to total reports for sarecycline.

1
Headache11.0%20
2
Drug Ineffective8.2%15
3
Dizziness7.1%13
4
Vision Blurred5.5%10
5
Rash4.9%9
6
Fatigue4.4%8
7
Anxiety3.8%7
8
Pruritus3.8%7
9
Seizure3.3%6
10
Syncope3.3%6
11
Condition Aggravated3.3%6
12
Erythema3.3%6
13
Product Dose Omission Issue3.3%6
14
Migraine2.7%5
15
Acne2.7%5

These are voluntary reports and do not establish that sarecycline caused these reactions.

Report severity

22.5%Serious41 reports
8.2%Hospitalizations15 reports
0.0%Fatal0 reports

Seriousness is determined by the reporter, not by OpenClaim.

Sarecycline drug interactions

Other drugs that appear in adverse event reports alongside sarecycline. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Dupilumab8.2%15
2
Copper2.2%4
3
Leniolisib-phosphate2.2%4
4
Tazarotene1.6%3
5
Adalimumab1.1%2
6
Adapalene1.1%2
7
Benzoyl-peroxide1.1%2
8
Spironolactone1.1%2
9
Calcium-oxybate1.1%2
10
Magnesium-oxybate1.1%2
11
Potassium-oxybate1.1%2
12
Sodium-oxybate1.1%2
13
Clascoterone1.1%2
14
Tofacitinib0.5%1
15
Glycopyrronium-tosylate0.5%1

Taken alongside

1
Ergocalciferol6.0%11
2
Clindamycin4.9%9
3
Ascorbic-acid4.9%9
4
Epinephrine4.9%9
5
Spironolactone3.8%7
6
Tretinoin3.8%7
7
Albuterol3.8%7
8
Cetirizine-hydrochloride3.8%7
9
Acetaminophen3.8%7
10
Ethinyl-estradiol2.7%5
11
Ondansetron2.7%5
12
Bupropion2.7%5
13
Clascoterone2.7%5
14
Omeprazole2.2%4
15
Benzoyl-peroxide2.2%4

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports sarecycline side effects

30.8% of sarecycline adverse event reports involve female patients and 14.8% involve male patients. The largest age group is adult at 73%. These figures reflect who reports side effects, not underlying risk.

Sex

Female30.8%
Male14.8%
Unknown54.4%

Age group

< 20.0%
2–110.0%
12–1723.9%
18–6473.1%
65+3.0%

What is sarecycline used for

Conditions and purposes for which patients were taking sarecycline when the adverse event was reported.

AcneAcne CysticAcneAcne CysticAttention Deficit Hyperactivity DisorderDermatitis AtopicHidradenitisHidradenitisInsomniaMucous Membrane PemphigoidProduct Used For Unknown IndicationProduct Used For Unknown IndicationRosaceaRosaceaStaphylococcal Bacteraemia

Showing 15 of 16 indications

Sarecycline brand names and reporting trend

Sarecycline is sold under the brand name Seysara.

Brand names

Seysara12

Quarterly reports (20192025)

20192020202220242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking sarecycline with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.