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Samarium Side Effects

The most commonly reported side effects of samarium include thrombocytopenia, pain, and thrombocytopenia, based on 162 FDA adverse event reports from 2004 to 2025. 6.2% of reports found the drug to be ineffective.

Samarium side effects

Percentages show how often each reaction appears relative to total reports for samarium.

1
Thrombocytopenia9.9%16
2
Pain8.6%14
3
Thrombocytopenia8.0%13
4
Pancytopenia8.0%13
5
Disease Progression8.0%13
6
Nausea6.8%11
7
Drug Ineffective6.2%10
8
Malignant Neoplasm Progression5.6%9
9
Bone Sarcoma5.6%9
10
Asthenia4.9%8
11
Dyspnoea4.9%8
12
Vomiting4.9%8
13
Haemoglobin Decreased4.9%8
14
Anaemia4.9%8
15
Back Pain4.3%7

These are voluntary reports and do not establish that samarium caused these reactions.

Report severity

87.7%Serious142 reports
55.6%Hospitalizations90 reports
22.2%Fatal36 reports

Seriousness is determined by the reporter, not by OpenClaim.

Samarium drug interactions

Other drugs that appear in adverse event reports alongside samarium. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Zoledronic-acid27.8%45
2
Ergocalciferol3.7%6
3
Docetaxel3.1%5
4
Denosumab3.1%5
5
Bortezomib2.5%4
6
Bevacizumab2.5%4
7
Capecitabine1.9%3
8
Pamidronate-disodium1.2%2
9
Abiraterone-acetate1.2%2
10
Enzalutamide1.2%2
11
Palbociclib1.2%2
12
Apomorphine-hydrochloride0.6%1
13
Selenium-sulfide0.6%1
14
Epoetin0.6%1
15
Abarelix0.6%1

Taken alongside

1
Acetaminophen13.6%22
2
Oxycodone13.0%21
3
Dexamethasone9.9%16
4
Tamsulosin-hydrochloride9.3%15
5
Prednisone8.6%14
6
Fentanyl8.0%13
7
Aspirin7.4%12
8
Hydrochlorothiazide7.4%12
9
Leuprolide6.8%11
10
Apomorphine-hydrochloride6.8%11
11
Warfarin6.8%11
12
Morphine-sulfate6.8%11
13
Zoledronic-acid6.8%11
14
Metoprolol6.2%10
15
Lorazepam6.2%10

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports samarium side effects

21.0% of samarium adverse event reports involve female patients and 71.0% involve male patients. The largest age group is adult at 48%. These figures reflect who reports side effects, not underlying risk.

Sex

Female21.0%
Male71.0%
Unknown8.0%

Age group

< 20.9%
2–111.8%
12–176.4%
18–6447.7%
65+43.1%

What is samarium used for

Conditions and purposes for which patients were taking samarium when the adverse event was reported.

Analgesic TherapyBladder CancerBone Cancer MetastaticBone PainBone SarcomaBreast CancerBreast Cancer MetastaticBreast Cancer RecurrentHormone-refractory Prostate CancerMetastases To BoneMetastatic PainMultiple MyelomaOsteosarcoma MetastaticPainPalliative Care

Showing 15 of 21 indications

Samarium brand names and reporting trend

Samarium is sold under the brand name Quadramet.

Brand names

Quadramet54

Quarterly reports (20042025)

2005201020152025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking samarium with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.