The most commonly reported side effects of sacubitril include hypotension, death, and dyspnoea, based on 115,125 FDA adverse event reports from 2012 to 2025. 2.3% of reports found the drug to be ineffective.
Percentages show how often each reaction appears relative to total reports for sacubitril.
These are voluntary reports and do not establish that sacubitril caused these reactions.
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Other drugs that appear in adverse event reports alongside sacubitril. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.
Also suspected
Taken alongside
Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.
33.2% of sacubitril adverse event reports involve female patients and 59.3% involve male patients. The largest age group is elderly at 62%. These figures reflect who reports side effects, not underlying risk.
Sex
Age group
Conditions and purposes for which patients were taking sacubitril when the adverse event was reported.
Showing 15 of 596 indications
Sacubitril is sold under the brand name Entresto Sprinkle.
An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.
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