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Sacituzumab Side Effects

The most commonly reported side effects of sacituzumab include disease progression, death, and diarrhoea, based on 5,359 FDA adverse event reports from 2010 to 2025.

Sacituzumab side effects

Percentages show how often each reaction appears relative to total reports for sacituzumab.

1
Disease Progression28.4%1,524
2
Death13.2%708
3
Diarrhoea12.2%655
4
Neutropenia10.8%581
5
Inappropriate Schedule Of Product Administration6.8%367
6
Fatigue6.2%331
7
Nausea5.9%314
8
Off Label Use5.6%301
9
Asthenia5.1%271
10
Febrile Neutropenia4.6%246
11
Alopecia3.8%203
12
Weight Fluctuation3.6%192
13
Vomiting3.4%181
14
Neutrophil Count Decreased3.2%172
15
Weight Decreased3.1%168

These are voluntary reports and do not establish that sacituzumab caused these reactions.

Report severity

91.4%Serious4,900 reports
27.7%Hospitalizations1,483 reports
23.1%Fatal1,237 reports

Seriousness is determined by the reporter, not by OpenClaim.

Sacituzumab drug interactions

Other drugs that appear in adverse event reports alongside sacituzumab. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Pembrolizumab2.5%132
2
Paclitaxel1.6%86
3
Carboplatin1.5%78
4
Capecitabine1.4%75
5
Atezolizumab1.1%61
6
Doxorubicin-hydrochloride1.1%59
7
Trastuzumab0.9%47
8
Gemcitabine0.8%45
9
Eribulin-mesylate0.7%38
10
Cyclophosphamide0.6%33
11
Filgrastim0.6%31
12
Diphenhydramine0.6%30
13
Bevacizumab0.6%30
14
Pegfilgrastim0.5%29
15
Epirubicin-hydrochloride0.5%25

Taken alongside

1
Acetaminophen8.4%450
2
Dexamethasone8.2%440
3
Ondansetron6.0%319
4
Diphenhydramine4.3%232
5
Famotidine4.0%213
6
Loperamide-hydrochloride3.1%168
7
Palonosetron-hydrochloride2.8%149
8
Paclitaxel2.6%142
9
Levothyroxine-sodium2.6%137
10
Capecitabine2.4%128
11
Omeprazole2.3%124
12
Pantoprazole-sodium2.2%120
13
Oxycodone1.9%101
14
Filgrastim1.9%101
15
Sodium-chloride1.7%91

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports sacituzumab side effects

87.0% of sacituzumab adverse event reports involve female patients and 6.7% involve male patients. The largest age group is adult at 71%. These figures reflect who reports side effects, not underlying risk.

Sex

Female87.0%
Male6.7%
Unknown6.3%

Age group

< 2<0.1%
2–110.0%
12–170.0%
18–6471.5%
65+28.5%

What is sacituzumab used for

Conditions and purposes for which patients were taking sacituzumab when the adverse event was reported.

Abdominal PainAdenocarcinoma Of The CervixAdverse Drug ReactionBladder CancerBreast CancerBreast Cancer FemaleBreast Cancer MetastaticBreast Cancer Stage IvBile Duct CancerBladder CancerBladder Cancer Stage IvBladder NeoplasmBladder Transitional Cell CarcinomaBladder Transitional Cell Carcinoma MetastaticBone Cancer

Showing 15 of 146 indications

Sacituzumab brand names and reporting trend

Sacituzumab is sold under the brand name Trodelvy.

Brand names

Trodelvy6,519

Quarterly reports (20102025)

202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking sacituzumab with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.