OpenClaim

Rucaparib Side Effects

The most commonly reported side effects of rucaparib include fatigue, nausea, and malignant neoplasm progression, based on 8,731 FDA adverse event reports from 2013 to 2025. 5.9% of reports found the drug to be ineffective.

Rucaparib side effects

Percentages show how often each reaction appears relative to total reports for rucaparib.

1
Fatigue29.1%2,540
2
Nausea25.8%2,254
3
Malignant Neoplasm Progression13.5%1,183
4
Decreased Appetite9.2%799
5
Diarrhoea9.0%788
6
Constipation8.9%781
7
Vomiting8.9%780
8
Asthenia7.7%675
9
Adverse Event6.5%571
10
Carbohydrate Antigen 125 Increased6.5%569
11
Dysgeusia6.5%565
12
Anaemia6.3%549
13
Product Dose Omission Issue6.3%546
14
Platelet Count Decreased6.2%538
15
Drug Ineffective5.9%516

These are voluntary reports and do not establish that rucaparib caused these reactions.

Report severity

43.1%Serious3,767 reports
16.8%Hospitalizations1,464 reports
5.7%Fatal500 reports

Seriousness is determined by the reporter, not by OpenClaim.

Rucaparib drug interactions

Other drugs that appear in adverse event reports alongside rucaparib. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Nivolumab2.3%197
2
Bevacizumab0.7%60
3
Atezolizumab0.5%45
4
Niraparib-tosylate0.5%44
5
Carboplatin0.4%37
6
Ondansetron0.4%34
7
Paclitaxel0.4%32
8
Enzalutamide0.3%30
9
Docetaxel0.3%29
10
Doxorubicin-hydrochloride0.3%27
11
Abiraterone-acetate0.3%25
12
Gemcitabine0.2%20
13
Warfarin0.2%19
14
Olaparib0.2%19
15
Cabazitaxel0.2%17

Taken alongside

1
Ondansetron7.6%662
2
Ergocalciferol5.0%437
3
Acetaminophen4.8%422
4
Levothyroxine-sodium4.7%406
5
Prochlorperazine4.1%355
6
Gabapentin3.4%294
7
Omeprazole3.3%291
8
Amlodipine3.1%274
9
Aspirin2.9%255
10
Lorazepam2.9%253
11
Atorvastatin-calcium2.7%233
12
Metoprolol2.6%228
13
Lisinopril2.5%219
14
Oxycodone2.5%216
15
Magnesium-acetate-tetrahydrate2.2%191

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports rucaparib side effects

89.0% of rucaparib adverse event reports involve female patients and 6.9% involve male patients. The largest age group is elderly at 52%. These figures reflect who reports side effects, not underlying risk.

Sex

Female89.0%
Male6.9%
Unknown4.1%

Age group

< 20.0%
2–110.0%
12–17<0.1%
18–6448.3%
65+51.7%

What is rucaparib used for

Conditions and purposes for which patients were taking rucaparib when the adverse event was reported.

Abdominal NeoplasmAdenocarcinomaAdenocarcinoma Of ColonAdenocarcinoma PancreasAgranulocytosisAnaemiaAnal CancerAtrial FibrillationAdenocarcinomaAdenocarcinoma Of AppendixAdrenocortical CarcinomaAgranulocytosisAplastic AnaemiaAppendix CancerB-cell Lymphoma

Showing 15 of 252 indications

Rucaparib brand names and reporting trend

Rucaparib is sold under the brand name Rubraca.

Brand names

Rubraca583

Quarterly reports (20132025)

2013202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking rucaparib with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.