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Rosiglitazone Side Effects

The most commonly reported side effects of rosiglitazone include myocardial infarction, cardiac failure congestive, and myocardial infarction, based on 103,327 FDA adverse event reports from 2004 to 2025.

Rosiglitazone side effects

Percentages show how often each reaction appears relative to total reports for rosiglitazone.

1
Myocardial Infarction20.7%21,387
2
Cardiac Failure Congestive17.8%18,379
3
Myocardial Infarction13.0%13,442
4
Cerebrovascular Accident9.7%10,055
5
Cardiac Failure Congestive8.1%8,359
6
Coronary Artery Disease6.1%6,300
7
Cerebrovascular Accident5.1%5,304
8
Death3.7%3,856
9
Cardiac Disorder3.7%3,776
10
Coronary Artery Disease3.2%3,341
11
Cardiac Disorder3.1%3,176
12
Acute Myocardial Infarction2.7%2,786
13
Blood Glucose Increased2.6%2,693
14
Nausea2.0%2,035
15
Dyspnoea1.8%1,880

These are voluntary reports and do not establish that rosiglitazone caused these reactions.

Report severity

86.3%Serious89,165 reports
52.3%Hospitalizations54,076 reports
13.7%Fatal14,119 reports

Seriousness is determined by the reporter, not by OpenClaim.

Rosiglitazone drug interactions

Other drugs that appear in adverse event reports alongside rosiglitazone. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Metformin12.0%12,348
2
Exenatide-synthetic3.6%3,727
3
Glimepiride1.9%1,978
4
Pioglitazone-hydrochloride0.8%835
5
Insulin0.5%501
6
Quetiapine-fumarate0.4%382
7
Sitagliptin0.4%369
8
Esomeprazole0.2%249
9
Atorvastatin-calcium0.2%247
10
Rofecoxib0.2%246
11
Rosuvastatin0.2%220
12
Omeprazole0.2%217
13
Simvastatin0.2%208
14
Pantoprazole-sodium0.2%172
15
Hydrochlorothiazide0.2%169

Taken alongside

1
Aspirin11.5%11,838
2
Metformin10.5%10,814
3
Lisinopril6.6%6,799
4
Furosemide6.4%6,638
5
Metoprolol6.1%6,312
6
Clopidogrel-bisulfate5.0%5,186
7
Hydrochlorothiazide4.2%4,362
8
Insulin4.2%4,324
9
Atorvastatin-calcium4.1%4,271
10
Amlodipine3.8%3,902
11
Simvastatin3.7%3,783
12
Glipizide3.4%3,466
13
Glyburide2.9%3,043
14
Carvedilol2.7%2,822
15
Atenolol2.5%2,589

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports rosiglitazone side effects

35.6% of rosiglitazone adverse event reports involve female patients and 44.7% involve male patients. The largest age group is adult at 67%. These figures reflect who reports side effects, not underlying risk.

Sex

Female35.6%
Male44.7%
Unknown19.7%

Age group

< 2<0.1%
2–11<0.1%
12–17<0.1%
18–6466.8%
65+33.1%

What is rosiglitazone used for

Conditions and purposes for which patients were taking rosiglitazone when the adverse event was reported.

Accidental ExposureAcneAcute Lymphocytic LeukaemiaAmnesiaAntibiotic TherapyArthritisAsthmaBenign Prostatic HyperplasiaBlood Cholesterol IncreasedBlood GlucoseBlood Glucose AbnormalBlood Glucose DecreasedBlood Glucose FluctuationBlood Glucose IncreasedBlood Insulin Abnormal

Showing 15 of 104 indications

Rosiglitazone brand names and reporting trend

Rosiglitazone is sold under the brand name Rosiglitazone Maleate And Glimepiride.

Brand names

Rosiglitazone Maleate And Glimepiride2

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking rosiglitazone with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.