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Ropivacaine Side Effects

The most commonly reported side effects of ropivacaine include vomiting, dyspnoea, and pneumonia, based on 4,869 FDA adverse event reports from 2004 to 2025. 6.7% of reports found the drug to be ineffective.

Ropivacaine side effects

Percentages show how often each reaction appears relative to total reports for ropivacaine.

1
Vomiting11.4%557
2
Dyspnoea11.1%542
3
Pneumonia10.7%519
4
Drug Hypersensitivity10.6%514
5
Oedema10.5%510
6
Asthma9.9%483
7
Wheezing9.8%476
8
Drug Ineffective6.7%325
9
Pain5.1%250
10
Hypotension4.8%234
11
Malaise4.2%203
12
Chest Pain3.6%176
13
Respiratory Tract Infection3.6%174
14
Cough3.2%157
15
Maternal Exposure During Pregnancy2.8%138

These are voluntary reports and do not establish that ropivacaine caused these reactions.

Report severity

91.4%Serious4,449 reports
34.9%Hospitalizations1,700 reports
5.0%Fatal242 reports

Seriousness is determined by the reporter, not by OpenClaim.

Ropivacaine drug interactions

Other drugs that appear in adverse event reports alongside ropivacaine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Lidocaine14.9%727
2
Propofol13.6%663
3
Tramadol-hydrochloride13.2%643
4
Fentanyl12.8%624
5
Hydromorphone-hydrochloride11.3%549
6
Ciprofloxacin10.5%513
7
Amlodipine10.4%506
8
Beclomethasone10.2%499
9
Montelukast-sodium10.2%499
10
Omalizumab10.2%499
11
Risedronate-sodium10.2%499
12
Rosuvastatin10.2%499
13
Rituximab10.2%497
14
Moxifloxacin-hydrochloride10.2%495
15
Clonazepam10.1%491

Taken alongside

1
Fentanyl9.3%452
2
Propofol8.8%427
3
Acetaminophen8.5%415
4
Lidocaine5.8%280
5
Epinephrine4.8%236
6
Midazolam4.4%213
7
Sufentanil-citrate4.2%204
8
Dexamethasone3.6%177
9
Rocuronium-bromide3.5%172
10
Apomorphine-hydrochloride3.1%149
11
Ondansetron3.0%148
12
Sodium-chloride2.9%142
13
Sevoflurane2.9%141
14
Cefazolin-sodium2.8%137
15
Oxycodone2.8%136

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports ropivacaine side effects

55.2% of ropivacaine adverse event reports involve female patients and 28.3% involve male patients. The largest age group is adult at 54%. These figures reflect who reports side effects, not underlying risk.

Sex

Female55.2%
Male28.3%
Unknown16.4%

Age group

< 24.1%
2–112.7%
12–173.0%
18–6454.1%
65+36.1%

What is ropivacaine used for

Conditions and purposes for which patients were taking ropivacaine when the adverse event was reported.

Abdominal OperationAbdominal PainAbdominal Pain UpperAbortion InducedAllergy TestAnaesthesiaAnaesthesia EyeAnaesthesia ProcedureAnalgesiaAnalgesic EffectAnalgesic Intervention Supportive TherapyAnalgesic TherapyAneurysmal Bone CystAngina PectorisAngle Closure Glaucoma

Showing 15 of 291 indications

Ropivacaine brand names and reporting trend

Ropivacaine is sold under the brand name Naropin.

Brand names

Naropin27

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking ropivacaine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.