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Ropinirole Side Effects

The most commonly reported side effects of ropinirole include fall, fatigue, and nausea, based on 35,974 FDA adverse event reports from 2004 to 2025. 5.5% of reports found the drug to be ineffective.

Ropinirole side effects

Percentages show how often each reaction appears relative to total reports for ropinirole.

1
Drug Ineffective5.5%1,983
2
Fall5.2%1,885
3
Fatigue4.9%1,749
4
Nausea4.7%1,706
5
Dizziness3.5%1,262
6
Pain3.3%1,195
7
Dyspnoea3.2%1,143
8
Hallucination3.0%1,095
9
Diarrhoea3.0%1,080
10
Headache2.9%1,046
11
Death2.9%1,029
12
Asthenia2.8%1,002
13
Drug Ineffective2.7%987
14
Off Label Use2.7%954
15
Insomnia2.6%929

These are voluntary reports and do not establish that ropinirole caused these reactions.

Report severity

60.3%Serious21,680 reports
28.6%Hospitalizations10,291 reports
7.2%Fatal2,592 reports

Seriousness is determined by the reporter, not by OpenClaim.

Ropinirole drug interactions

Other drugs that appear in adverse event reports alongside ropinirole. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Levodopa7.8%2,811
2
Carbidopa6.6%2,358
3
Sodium-oxybate4.7%1,692
4
Pimavanserin3.6%1,302
5
Adalimumab2.7%988
6
Lenalidomide2.2%779
7
Pregabalin2.1%738
8
Omeprazole1.9%700
9
Entacapone1.9%671
10
Esomeprazole1.8%648
11
Lansoprazole1.7%604
12
Gabapentin1.4%520
13
Pramipexole-dihydrochloride1.4%505
14
Apomorphine-hydrochloride1.4%502
15
Amantadine1.4%502

Taken alongside

1
Gabapentin17.0%6,103
2
Acetaminophen16.9%6,084
3
Aspirin16.2%5,838
4
Levothyroxine-sodium15.7%5,660
5
Ergocalciferol15.3%5,514
6
Omeprazole14.1%5,084
7
Levodopa12.5%4,502
8
Furosemide12.5%4,494
9
Carbidopa12.0%4,314
10
Albuterol11.9%4,289
11
Atorvastatin-calcium11.7%4,223
12
Metoprolol10.0%3,610
13
Fluticasone9.7%3,476
14
Lisinopril9.5%3,426
15
Metformin8.7%3,116

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports ropinirole side effects

59.1% of ropinirole adverse event reports involve female patients and 33.7% involve male patients. The largest age group is elderly at 53%. These figures reflect who reports side effects, not underlying risk.

Sex

Female59.1%
Male33.7%
Unknown7.2%

Age group

< 2<0.1%
2–110.1%
12–17<0.1%
18–6446.5%
65+53.2%

What is ropinirole used for

Conditions and purposes for which patients were taking ropinirole when the adverse event was reported.

Accidental ExposureAccidental Exposure To ProductAdjuvant TherapyAdverse Drug ReactionAffective DisorderAgitationAkathisiaAkinesiaAmyotrophic Lateral SclerosisAnalgesic TherapyAnticoagulant TherapyAntidepressant TherapyAnxietyApathyApnoea

Showing 15 of 327 indications

Ropinirole brand names and reporting trend

Ropinirole is sold under the brand name Ropinirole Hydrochloride.

Brand names

Ropinirole Hydrochloride276

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking ropinirole with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.