OpenClaim

Ropeginterferon Side Effects

The most commonly reported side effects of ropeginterferon include fatigue, off label use, and rash, based on 7,624 FDA adverse event reports from 2004 to 2025. 4.3% of reports found the drug to be ineffective.

Ropeginterferon side effects

Percentages show how often each reaction appears relative to total reports for ropeginterferon.

1
Fatigue8.5%647
2
Off Label Use6.3%479
3
Rash6.2%474
4
Anaemia6.2%473
5
Nausea5.5%417
6
Pruritus5.1%386
7
Drug Ineffective4.3%326
8
Headache4.0%307
9
Diarrhoea3.6%274
10
Pyrexia3.5%265
11
Pain3.0%227
12
Asthenia2.8%215
13
Vomiting2.7%209
14
Dizziness2.6%195
15
Depression2.5%190

These are voluntary reports and do not establish that ropeginterferon caused these reactions.

Report severity

63.9%Serious4,874 reports
22.7%Hospitalizations1,728 reports
8.0%Fatal607 reports

Seriousness is determined by the reporter, not by OpenClaim.

Ropeginterferon drug interactions

Other drugs that appear in adverse event reports alongside ropeginterferon. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Ribavirin29.0%2,213
2
Telaprevir18.2%1,388
3
Sofosbuvir3.5%266
4
Boceprevir2.3%172
5
Imatinib-mesylate2.0%155
6
Bevacizumab1.8%136
7
Peginterferon1.6%119
8
Hydroxyurea1.3%99
9
Zoledronic-acid1.2%95
10
Prednisone1.1%86
11
Epoetin1.1%85
12
Everolimus1.1%82
13
Sorafenib-tosylate0.9%72
14
Tenofovir0.9%70
15
Doxorubicin-hydrochloride0.9%69

Taken alongside

1
Ribavirin17.8%1,360
2
Aspirin8.0%612
3
Acetaminophen3.9%299
4
Hydroxyurea3.2%244
5
Ergocalciferol3.0%228
6
Levothyroxine-sodium2.9%219
7
Omeprazole2.5%187
8
Amlodipine2.2%170
9
Lisinopril1.8%139
10
Atorvastatin-calcium1.7%132
11
Ibuprofen1.7%129
12
Furosemide1.7%128
13
Metoprolol1.6%125
14
Prednisone1.6%123
15
Hydrochlorothiazide1.6%123

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports ropeginterferon side effects

41.4% of ropeginterferon adverse event reports involve female patients and 46.4% involve male patients. The largest age group is adult at 79%. These figures reflect who reports side effects, not underlying risk.

Sex

Female41.4%
Male46.4%
Unknown12.2%

Age group

< 20.9%
2–110.9%
12–170.6%
18–6479.4%
65+18.3%

What is ropeginterferon used for

Conditions and purposes for which patients were taking ropeginterferon when the adverse event was reported.

Acquired Immunodeficiency SyndromeAcute Hepatitis BAcute Lymphocytic LeukaemiaAcute Lymphocytic LeukemiaAcute Myeloid LeukaemiaAdenocarcinoma PancreasAdjuvant TherapyAdult T-cell Lymphoma/leukaemiaAlveolar Soft Part SarcomaAnaplastic AstrocytomaAngioimmunoblastic T-cell LymphomaAntiviral TreatmentAspergillosisAspergillus InfectionAutoimmune Disorder

Showing 15 of 293 indications

Ropeginterferon brand names and reporting trend

Ropeginterferon is sold under the brand name Besremi.

Brand names

Besremi6,617

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking ropeginterferon with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.