OpenClaim

Romiplostim Side Effects

The most commonly reported side effects of romiplostim include platelet count decreased, off label use, and platelet count abnormal, based on 14,653 FDA adverse event reports from 2008 to 2025. 6.5% of reports found the drug to be ineffective.

Romiplostim side effects

Percentages show how often each reaction appears relative to total reports for romiplostim.

1
Platelet Count Decreased8.4%1,232
2
Off Label Use7.9%1,157
3
Drug Ineffective6.5%954
4
Platelet Count Abnormal5.6%814
5
Drug Ineffective5.1%746
6
Therapeutic Response Decreased4.4%648
7
Death3.6%524
8
Thrombocytopenia3.4%495
9
Platelet Count Decreased3.2%475
10
Death3.2%468
11
Headache3.0%439
12
Thrombocytopenia3.0%438
13
Product Storage Error2.3%344
14
Fatigue2.2%329
15
Therapeutic Response Decreased2.0%295

These are voluntary reports and do not establish that romiplostim caused these reactions.

Report severity

76.9%Serious11,270 reports
25.5%Hospitalizations3,730 reports
17.9%Fatal2,626 reports

Seriousness is determined by the reporter, not by OpenClaim.

Romiplostim drug interactions

Other drugs that appear in adverse event reports alongside romiplostim. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Rituximab4.1%597
2
Eltrombopag2.9%425
3
Fostamatinib-disodium2.4%351
4
Prednisone2.4%346
5
Dexamethasone2.1%303
6
Cyclosporine1.5%225
7
Vincristine-sulfate1.4%209
8
Prednisolone1.4%203
9
Mycophenolate1.3%184
10
Azathioprine1.2%171
11
Cyclophosphamide1.0%152
12
Danazol0.9%130
13
Filgrastim0.9%126
14
Methylprednisolone0.7%97
15
Ascorbic-acid0.6%84

Taken alongside

1
Prednisone7.3%1,073
2
Rituximab5.5%803
3
Acetaminophen2.9%428
4
Eltrombopag2.6%388
5
Dexamethasone2.6%387
6
Furosemide2.5%363
7
Omeprazole2.3%342
8
Levothyroxine-sodium2.3%332
9
Amlodipine2.1%315
10
Prednisolone2.0%296
11
Metoprolol2.0%290
12
Cyclosporine1.8%261
13
Insulin1.8%260
14
Pantoprazole-sodium1.7%246
15
Lisinopril1.7%242

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports romiplostim side effects

43.6% of romiplostim adverse event reports involve female patients and 37.8% involve male patients. The largest age group is adult at 50%. These figures reflect who reports side effects, not underlying risk.

Sex

Female43.6%
Male37.8%
Unknown18.6%

Age group

< 21.1%
2–113.4%
12–172.7%
18–6449.5%
65+43.3%

What is romiplostim used for

Conditions and purposes for which patients were taking romiplostim when the adverse event was reported.

Acquired Amegakaryocytic ThrombocytopeniaAcute Graft Versus Host Disease In SkinAcute Lymphocytic LeukaemiaAcute Myeloid LeukaemiaAdenocarcinomaAdverse EventAgranulocytosisAmegakaryocytic ThrombocytopeniaAnaemiaAngle Closure GlaucomaAplasiaAplasia Pure Red CellAplastic AnaemiaAutoimmune DisorderAutoimmune Haemolytic Anaemia

Showing 15 of 272 indications

Romiplostim brand names and reporting trend

Romiplostim is sold under the brand name Nplate.

Brand names

Nplate5,125

Quarterly reports (20082025)

20082010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking romiplostim with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.