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Rolapitant Side Effects

The most commonly reported side effects of rolapitant include death, nausea, and flushing, based on 1,103 FDA adverse event reports from 2013 to 2025.

Rolapitant side effects

Percentages show how often each reaction appears relative to total reports for rolapitant.

1
Death23.7%261
2
Nausea14.0%154
3
Flushing8.5%94
4
Fatigue8.2%90
5
Dyspnoea7.2%79
6
Infusion Related Reaction5.9%65
7
Decreased Appetite5.3%59
8
Diarrhoea5.1%56
9
Erythema5.0%55
10
Dizziness4.9%54
11
Feeling Hot4.3%47
12
Vomiting4.1%45
13
Back Pain3.8%42
14
Hospitalisation3.5%39
15
Platelet Count Decreased3.3%36

These are voluntary reports and do not establish that rolapitant caused these reactions.

Report severity

72.4%Serious799 reports
19.6%Hospitalizations216 reports
26.0%Fatal287 reports

Seriousness is determined by the reporter, not by OpenClaim.

Rolapitant drug interactions

Other drugs that appear in adverse event reports alongside rolapitant. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Selinexor14.3%158
2
Cisplatin1.7%19
3
Fluorouracil1.3%14
4
Trastuzumab1.3%14
5
Docetaxel1.2%13
6
Dexamethasone1.2%13
7
Pertuzumab1.1%12
8
Carboplatin1.0%11
9
Pomalidomide0.9%10
10
Oxaliplatin0.8%9
11
Cyclophosphamide0.7%8
12
Etoposide0.7%8
13
Cetuximab0.6%7
14
Paclitaxel0.5%6
15
Niraparib-tosylate0.5%6

Taken alongside

1
Dexamethasone17.1%189
2
Ondansetron13.3%147
3
Acyclovir8.1%89
4
Olanzapine5.7%63
5
Prochlorperazine4.4%48
6
Oxycodone4.0%44
7
Palonosetron-hydrochloride3.9%43
8
Aspirin3.0%33
9
Lorazepam3.0%33
10
Metoprolol2.9%32
11
Gabapentin2.9%32
12
Acetaminophen2.7%30
13
Levothyroxine-sodium2.6%29
14
Bortezomib2.6%29
15
Omeprazole2.4%27

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports rolapitant side effects

39.7% of rolapitant adverse event reports involve female patients and 27.9% involve male patients. The largest age group is adult at 58%. These figures reflect who reports side effects, not underlying risk.

Sex

Female39.7%
Male27.9%
Unknown32.4%

Age group

< 20.0%
2–110.0%
12–170.3%
18–6457.6%
65+42.2%

What is rolapitant used for

Conditions and purposes for which patients were taking rolapitant when the adverse event was reported.

Antiemetic Supportive CareBone CancerBreast Cancer FemaleCervix CarcinomaChemotherapyCholangiocarcinomaColon CancerCyclic Vomiting SyndromeDuctal Adenocarcinoma Of PancreasEndometrial CancerGastrointestinal Cancer MetastaticGenital Neoplasm Malignant FemaleLung Carcinoma Cell Type Unspecified Stage 0Lung Neoplasm MalignantMalignant Connective Tissue Neoplasm

Showing 15 of 35 indications

Rolapitant brand names and reporting trend

Rolapitant is sold under the brand name Varubi.

Brand names

Varubi917

Quarterly reports (20132025)

20132016202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking rolapitant with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.