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Rizatriptan Side Effects

The most commonly reported side effects of rizatriptan include nausea, headache, and migraine, based on 15,999 FDA adverse event reports from 2004 to 2025. 12.4% of reports found the drug to be ineffective.

Rizatriptan side effects

Percentages show how often each reaction appears relative to total reports for rizatriptan.

1
Drug Ineffective12.4%1,979
2
Nausea9.6%1,530
3
Headache8.8%1,402
4
Migraine8.4%1,348
5
Off Label Use6.9%1,099
6
Fatigue6.1%974
7
Pain4.9%779
8
Vomiting4.0%644
9
Product Use In Unapproved Indication4.0%638
10
Dizziness4.0%633
11
Diarrhoea3.9%626
12
Arthralgia3.4%547
13
Dyspnoea3.4%538
14
Anxiety3.0%487
15
Hyperhidrosis3.0%483

These are voluntary reports and do not establish that rizatriptan caused these reactions.

Report severity

57.7%Serious9,232 reports
20.6%Hospitalizations3,290 reports
2.0%Fatal325 reports

Seriousness is determined by the reporter, not by OpenClaim.

Rizatriptan drug interactions

Other drugs that appear in adverse event reports alongside rizatriptan. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Sodium-oxybate9.3%1,490
2
Topiramate6.9%1,096
3
Acetaminophen5.6%898
4
Propranolol-hydrochloride4.9%784
5
Erenumab-aooe4.4%711
6
Venlafaxine4.3%689
7
Duloxetine-hydrochloride4.2%666
8
Hydromorphone-hydrochloride4.0%638
9
Sumatriptan4.0%634
10
Gabapentin3.8%608
11
Ibuprofen3.7%597
12
Amitriptyline-hydrochloride3.5%564
13
Esomeprazole3.5%564
14
Onabotulinumtoxina3.4%540
15
Diclofenac3.3%525

Taken alongside

1
Acetaminophen22.1%3,531
2
Ergocalciferol16.7%2,669
3
Topiramate14.0%2,238
4
Albuterol13.9%2,230
5
Gabapentin12.9%2,062
6
Fluticasone12.4%1,989
7
Ondansetron11.9%1,910
8
Levothyroxine-sodium11.4%1,822
9
Omeprazole11.0%1,767
10
Ibuprofen10.3%1,643
11
Duloxetine-hydrochloride9.6%1,540
12
Prednisone8.3%1,322
13
Aspirin7.8%1,242
14
Pantoprazole-sodium7.7%1,238
15
Montelukast-sodium7.6%1,213

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports rizatriptan side effects

78.7% of rizatriptan adverse event reports involve female patients and 13.1% involve male patients. The largest age group is adult at 86%. These figures reflect who reports side effects, not underlying risk.

Sex

Female78.7%
Male13.1%
Unknown8.2%

Age group

< 20.6%
2–110.6%
12–172.2%
18–6486.2%
65+10.4%

What is rizatriptan used for

Conditions and purposes for which patients were taking rizatriptan when the adverse event was reported.

Abdominal DiscomfortAbdominal PainAnalgesic TherapyAnxietyArachnoid CystArthritisAsthmaAtrial FibrillationAttention Deficit Hyperactivity DisorderAbdominal MigraineAnxietyAttention Deficit Hyperactivity DisorderBipolar DisorderBlindnessBlood Pressure Abnormal

Showing 15 of 122 indications

Rizatriptan brand names and reporting trend

Rizatriptan is sold under the brand name Maxalt.

Brand names

Maxalt8,238

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking rizatriptan with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.